Nucleic acids encoding TIE-2 ligand-2

Details Nucleic acids encoding TIE-2 ligand-2 Nucleic acids encoding TIE-2 ligand-2

1995-04-06

1998-09-29

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 701, 4352402, 4352523, 4353201, 935 22, 935 69, 935 70, 935 72, 536 231, 536 235, C12N 1512, C07K 14435

Patent

active

058144641

ABSTRACT:
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

REFERENCES:
Partanen et al. (1990) Proc. Natl. Acad. Sci. vol. 87, pp. 8913-8917.
Partanen et al. (1992) Mol. & Cell. Biology, vol. 12, No. 4, pp. 1698-1707.

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