Method of producing 4-hydroxy-2-pyrrolidinone and method of puri

Details Method of producing 4-hydroxy-2-pyrrolidinone and method of puri Method of producing 4-hydroxy-2-pyrrolidinone and method of puri

1999-05-25

2000-02-29

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20712

Patent

active

060311134

ABSTRACT:
4-Hydroxy-2-pyrrolidinone which is useful as a raw material of drugs can be produced rapidly and highly selectively in a high yield from an optically active or recemic 4-amino-3-hydroxybutylic acid derivative or a 4-azido-3-hydroxybutyric acid derivative by adding a base catalyst to the reaction system. 4-Hydroxy-2-pyrrolidinone having a high optical purity can be obtained by carrying out recrystallization of optically active 4-hydroxy-2-pyrrolidinone without using a poor solvent.

REFERENCES:
patent: 5869694 (1999-02-01), Furukawa et al.
Larcheveque et al., Tetrahedron, 46:4277-4282 (1990).
Pellegata et al., Synthesis, 614-616 (Aug. 1978).
Kobayaski et al., "Preparation of optically active 2-pyrrolidinones as intermediates for antibacterial carbapenems", Chemical Abstracts, 125:1151, Aug. 26, 1996.

Affiliated with

Also associated with

Rating

Method of producing 4-hydroxy-2-pyrrolidinone and method of puri does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of producing 4-hydroxy-2-pyrrolidinone and method of puri, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of producing 4-hydroxy-2-pyrrolidinone and method of puri will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-684358