Forming thin film interfaced samples for analysis with capillary

Details Forming thin film interfaced samples for analysis with capillary Forming thin film interfaced samples for analysis with capillary

1996-09-20

1998-09-29

Warden, Robert J.

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

204604, G01N 2726, G01N 27447

Patent

active

058141995

ABSTRACT:
Direct measurement of soluble ionogenic atmospheric gases is implemented using a suppressed conductometric capillary electrophoresis separation system. A small circular wire loop is incorporated adjacent sampling end of a fused silica capillary, in the same plane as the capillary. Dipping the loop into a solution and then withdrawing forms a liquid film that is in fluid communication with the capillary and acts as a microreservoir. Elevating the film relative to the destination side injects part or all of the film contents into the capillary. This mechanism may be used to perform gas sampling in automated fashion with slightly modified commercial CE instrumentation. The film-bearing loop is lowered into a sample chamber and air is sampled for a preset time period at a preselected flow rate. Lifting the capillary introduces an aliquot from the film for analysis. The capillary is then dipped into a running electrolyte source vial and electrophoresis is commenced. The system may be used with other than suppressed conductivity detection units and/or nonaqueous electrolytes.

REFERENCES:
patent: 5122248 (1992-06-01), Karger et al.
patent: 5358612 (1994-10-01), Dasgupta et al.
Donald J. Rose, Jr. and James W. Jorgenson, "Characterization and Automation of Sample Introduction Methods for Capillary Zone Electrophoresis" Analytical Chemistry, vol. 60, No. 7 (1 Apr. 1986) 642-648.
Susumu Honda et al, "Evaluation of an Automatic Siphonic Sampler for Capillary Zone Electrophoresis" Journal of Chromotography 404 (1987 No month available)313-320.
Cardoso, A.A. and P.K. Dasgupta, "Analytic Chemistry in a Liquid Film/Droplet," Analytical Chemistry, 67(15):2562-2566 (Aug. 1, 1995).
Liu, S. and Dasgupta, P.K., "Liquid Droplet. A Renewable Gas Sampling Interface," Analytical Chemistry, 67(13):2042-2049 (Jul. 1, 1995).
Dasgupta, P.K. and L. Bao, "Suppressed Conductometric Capillary Electrophoresis Separation System," Analytical Chemistry, 65(8):1003-1011 (Apr. 15, 1993).
Simon, P.K. and P.K. Dasgupta, "Wet Effluent Denuder Coupled Liquid/Ion chromotography Systems: Annular and Parallel Plate Denuders," Analytical Chemistry, 65(9):1134-1139 (May 1, 1993).
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