Reagent and method for radioimaging leukocytes

Details Reagent and method for radioimaging leukocytes Reagent and method for radioimaging leukocytes

1984-05-21

1987-01-06

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 85, 530387, 435 35, A61K 4300, A61K 4900

Patent

active

046345868

ABSTRACT:
Leukocytes are radioimmunoimaged by injecting patients with an immunoreactive nonleukocidal conjugate of an anti-leukocyte antibody and a gamma-emitting radioactive metal chelate, waiting for the conjugate to localize on the leukocytes, injecting the patient with an antibody to the conjugate to clear the blood of background nonlocalized conjugate, and visualizing the leukocytes by scintillation scanning.

REFERENCES:
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4497791 (1985-02-01), Gamble et al.
Meares et al., Proc. Natl. Acad. Sci. USA, 73 (1976) 3803-3806.
Sundberg et al., J. Med. Chem., 17 (1974) 1304-1307.
Colas-Linhart et al., Chem. Abstracts, 98 (1983) #103851f.
Begent et al., The Lancet, Oct. 2, 1982, 739-742.
Bradwell et al., The Lancet, Jan. 29, 1983, p. 247.

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