Methods of treating p150,95-mediated inflammation and ICAM-1-med

Details Methods of treating p150,95-mediated inflammation and ICAM-1-med Methods of treating p150,95-mediated inflammation and ICAM-1-med

1997-03-19

2000-02-29

Kemmerer, Elizabeth

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 2, A61K 3816, A61K 3817

Patent

active

060309474

ABSTRACT:
This invention concerns the cloning of the alpha-subunit of the p150,95 leukocyte adhesion receptor molecule. The invention also concerns the alpha-subunit of p150,95, as well as fragments of this receptor molecule. The invention further pertains to the diagnostic and therapeutic uses for such molecules.

REFERENCES:
patent: 4761371 (1988-08-01), Bell et al.
patent: 4935234 (1990-06-01), Todd, III et al.
patent: 4956281 (1990-09-01), Wallner et al.
patent: 5512660 (1996-04-01), Springer et al.
Bowie et al. Science 247:1306-1310, 1990.
Dransfield et al. Immunol. Rev. 114:29-44, 1990.
Hynes. Cell 69:11-25, Apr. 1992.
Anderson, D.C. et al., "Abnormalities of Polymorphonuclear Leukocyte Function Associated with a Heritable Deficiency of High Molecular Weight Surface Glycoproteins (GP 138) : Common Relationship to Diminished Cell Adherence," J. Clin. Invest. 74:536-551 (1984).
Anderson, D.C. et al., "Contributions Of The Mac-1 Glycoprotein Family To Adherence-Dependent Granulocyte Functions: Structure-Function Assessments Employing Subunit-Specific Monoclonal Antibodies," J. Immunol. 137(1) :15-27 (Jul. 1986).
Anderson, D.C. et al., "The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features," J. Inf. Dis. 152(4) :668-689 (1985).
Beller, D.I. et al., "Anti-Mac-1 Selectively Inhibits The Mouse And Human Type Three Complement Receptor," J. Exp. Med. 156:1000-1009 (1982).
Brian, A.A. et al., "Allogeneic stimulation of cytotoxic T cells by supported planar membranes," Proc. Natl. Acad. Sci. USA 81:6159-6163 (1984).
Bullock, W.E. et al., "Role Of The Adherence-Promoting Receptors, CR3, LFA-1, And p150, 95, In Binding Of Histoplasma capsulatum By Human Macrophages," J. Exp. Med. 165:195-210 (Jan. 1987).
Cerf-Bensussan, N. et al., "Immunohistologic And Immunoelectron Microscopic Characterization Of The Mucosal Lymphocytes Of Human Small Intestine By The Use Of Monoclonal Antibodies," J. Immunol. 130(6) :2615-2622 (1983).
Corbi, A. et al., "cDNA Cloning and Primary Sequence of the Alpha Subunit of p150,95," J. Cell. Biochem. Suppl. 11D, p. 268, Abstract No. T404 (Dec. 1987).
Corbi, A.L. et al., "cDNA cloning and complete primary structure of the .alpha. subunit of a leukocyte adhesion glycoprotein, p150,95," EMBO J. 6(13) :4023-4028 (Dec. 1987).
Cunningham, B.A. et al., "Neural Cell Adhesion Molecule: Structure, Immunoglobulin-Like Domains, Cell Surface Modulation, and Alternative RNA Splicing," Science 236:799-806 (May 1987).
Dana, N. et al., "Two Functional Domains In The Phagocyte Membrane Glycoprotein Mol Identified With Monoclonal Antibodies," J. Immunol. 137(10) :3259-3263 (Nov. 1986).
Davignon, D. et al., "Lymphocyte function-associated antigen 1 (LFA-1) : A surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing," Proc. Natl. Acad. Sci. USA 78(7) :4535-4539 (1981).
Detmers, P.A. et al., "Aggregation of Complement Receptors on Human Neutrophils in the Absence of Ligand," J. Cell Biol. 105:1137-1145 (Sep. 1987).
Dustin, M.L. et al., "Induction By IL 1 And Interferon-.gamma.: Tissue Distribution, Biochemistry, And Function Of A Natural Adherence Molecule (ICAM-1)," J. Immunol. 137(1) :245-254 (Jul. 1986).
Dustin, M.L. et al. "Purified Lymphocyte Function-Associated Antigen 3 Binds To CD2 And Mediates T Lymphocyte Adhesion," J. Exp. Med. 165:677-692 (Mar. 1987).
Fischer, A. et al., "Prevention Of Graft Failure By An Anti-HLFA-1 Monoclonal Antibody In HLA-Mismatched Bone-Marrow Transplantation," Lancet:1058-1061 (Nov. 1986).
Fischer, A. et al., "Role Of The LFA-1 Molecule In Cellular Interactions Required For Antibody Production In Humans," J. Immunol. 136(9) :3198-3203 (May 1986).
Gay, D. et al., "The Major Histocompatibility Complex-Restricted Antigen Receptor On T Cells," J. Immunol. 136(6) :2026-2032 (Mar. 1986).
Grossman, H.B., "Clinical Applications of Monoclonal Antibody Technology," Urologic Clinics of North America 13(3) :465-474 (Aug. 1986).
Harlan, J.M. et al., "The Role of Neutrophil Membrane Glycoprotein GP-150 in Neutrophil Adherence to Endothelium In Vitro," Blood 66(1) :167-178 (1985).
Haskard, D. et al., "T Lymphocyte Adhesion To Endothelial Cells: Mechanisms Demonstrated By Anti-LFA-1 Monoclonal Antibodies," J. Immunol. 137(9) :2901-2906 (Nov. 1986).
Hogg, N. et al., "The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules," Eur. J. Immunol. 16:240-248 (Mar. 1986).
Hynes, R.O., "Integrins: A Family of Cell Surface Receptors," Cell 48:549-554 (Feb. 1987).
Jones, D.H. et al., "Subcellular Location Of MAC-1 (CR-3) In Human Neutrophils: Effects Of Chemotactic Factors And PMA," Ped. Res. 21:312a, Abstract No. 835 (1987).
Keizer, G.D. et al., "Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1 and p150,95," Eur. J. Immunol. 15:1142-1147 (1985).
Keizer, G.D. et al., "Membrane Glycoprotein p150,95 Of Human Cytotoxic T Cell Clones Is Involved In Conjugate Formation With Target Cells," J. Immunol. 138(10) :3130-3136 (May 1987).
Keizer, G.D. et al., "Role of p150,95 in adhesion, migration, chemotaxis and phagocytosis of human monocytes," Eur. J. Immunol. 17:1317-1322 (Sep. 1987).
Khaw, B.A. et al., "Myocardial Infarct Imaging of Antibodies to Canine Cardiac Myosin with Indium-111-Diethylenetriamine Pentaacetic Acid," Science 209:295-297 (1980).
Kishimoto, T.K. et al., "Cloning of the .beta. Subunit of the Leukocyte Adhesion Proteins: Homology to an Extracellular Matrix Receptor Defines a Novel Supergene Family," Cell 48:681-690 (Feb. 1987).
Kishimoto, T.K. et al., "Cloning of the .beta. Subunit of LFA-1, Mac1, and p150,95: Homology to a fibronectin receptor and the molecular basis of leukocyte adhesion deficiency," Fed. Proc. 46:446, Abstract No. 755 (Mar. 1987).
Kishimoto, T.K. et al., "The .beta. Subunit of LFA-1, Mac-1, and p150,95: Gene Cloning, Homology To A Fibronectin Receptor, And The Molecular Basis Of Leukocyte Adhesion Deficiency," J. Cell. Biochem., Suppl. 11D, p. 271, Abstract No. T415 (Dec. 1987).
Kohl, S. et al., "The Genetic Deficiency Of Leukocyte Surface Glycoprotein Mac-1, LFA-1, p150,95 In Humans Is Associated With Defective Antibody-Dependent Cellular Cytotoxicity In Vitro And Defective Protection Against Herpes Simplex Virus Infection In Vivo," J. Immunol. 137(5) :1688-1694 (1986).
Krensky, A.M. et al., "LFA-1, LFA-2 and LFA-3 Antigens Are Involved in CTL-Target Conjugation," J. Immunol. 132(5) :2180-2182 (1984).
Lanier, L.L. et al., "p150/95, Third member of the LFA-1/CR.sub.3 polypeptide family identified by anti-Leu M5 monoclonal antibody," Eur. J. Immunol. 15:713-718 (1985).
Lathe, R., "Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data, Theoretical and Practical Considerations," J. Mol. Biol. 183:1-12 (1985).
Marlin, S.D. et al., "Purified Intercellular Adhesion Molecule-1 (ICAM-1) Is a Ligand for Lymphocyte Function-Associated Antigen 1 (LFA-1)," Cell 51:813-819 (Dec. 1987).
Martz, E., "Immune T Lymphocyte To Tumor Cell Adhesion," J. Cell Biol. 84:584-598 (1980).
Micklem, K.J. et al., "Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography," Biochem. J. 231:233-236 (1985).
Miller, L.J. et al., "Regulated Expression Of The Mac-1, LFA-1, p150,95 Glycoprotein Family During Leukocyte Differentiation," J. Immunol. 137(9) :2891-2900 (Nov. 1986).
Miller, L.J. et al., "Purification and .alpha. Subunit N-terminal Sequences of Human Mac-1 and p150,95 Leukocyte Adhesion Proteins," J. Immunol. 138:2381-2383 (Apr. 1987).
Mosser, D.M. et al. "The Mouse Macrophage Receptor For C3bi (CR3) Is A Major Mechanism In The Phagocytosis Of Leishmania Promastigotes," J. Immunol. 135(4) :2785-2789 (1985).
Patarroyo, M. et al., "Identification of a novel adhesion molecule in human leukocytes by monoclonal antibody LB-2," FEBS Letters 210(2) :127-131 (Jan. 1987).
Patarroyo, M. et al., "Identification Of A Cell-Surface Glycoprotein Mediating Cell Adhesion In EBV-Immortalized Normal B Cells,"

Affiliated with

Also associated with

Rating

Methods of treating p150,95-mediated inflammation and ICAM-1-med does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of treating p150,95-mediated inflammation and ICAM-1-med, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treating p150,95-mediated inflammation and ICAM-1-med will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-683050