Polynucleotides encoding G-protein parathyroid hormone receptor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 43525411, 435325, 4353201, 536 235, 536 2431, C12N 1512, C07K 14705

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060308044

ABSTRACT:
Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

REFERENCES:
Proc. Natl. Acad. Sci., USA, vol. 87, pp. 3052-3056, (Apr. 1990).
Science, vol. 244, pp. 569-572, (May 5, 1989).
FEBS 08897, vol. 271, No. 1, 2, pp. 81-84, (Oct. 1990).
The Journal of Biological Chemistry, vol. 265, No. 16, pp. 9308-9313, (Jan. 25, 1990).
FEBS 09821, vol. 284, pp. 155-160, (Jun. 1991).
The Journal of Biological Chemistry, vol. 270, No. 26, pp. 15455-15458, (1995).

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