Amino procollagen 1(I) peptides

Details Amino procollagen 1(I) peptides Amino procollagen 1(I) peptides

1995-06-07

1997-02-04

Ketter, James S.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

530324, 5303879, 530325, 530326, 530327, 530328, 530329, G01N 3353, C07K 1478

Patent

active

055996795

ABSTRACT:
Peptides which contain epitopes that mimic epitopes of the amino terminal propeptide of .alpha.1 Type I collagen, and antibodies which bind the epitopes, are useful in monitoring bone formation. Assays which employ the peptides and antibodies thereto are particularly useful in diagnosing and monitoring bone related disorders, such as osteoporosis and Paget's disease, among others.

REFERENCES:
Davis et al., "Development of a serum assay for procollagen type I aminopropeptitde," Gastroenterology 88 (5 pt 2): 1655. (May 1985).
Davis et al., "An Immunohistochemical and Serum ELISA study of type I and type III Procollagen Aminopeptides in Primary Biliary Cirrhosis," Am. J. of Pathology, 128(2):265-275 (Aug. 1987).
Simon et al, "Serum Levels of Type I and III Procollagen Fragments in Paget's Disease of the Bone," 58(1):110-120. (Jan. 1984).
Foellmer et al., "A Monoclonal Antibody Specific for the Amino Terminal Cleavage Site of Procollagen Type I," Eur. J. Biochem. 134:183-189 (1983).
Chu et al., "Human Pro.alpha.1 (I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons," Nature 310:337-340. (Jul. 1984).
Fessler et al., "Biosynthesis of Procollagen", Ann. Rev. Biochem. 47:129-162. (1978).
Fisher et al., "The M.sub.r 24,000 Phosphoprotein from Developing Bone is the NH.sub.2 -terminal Propeptide of the .alpha.1 Chain of Type I Collagen," J. Biol. Chem. 262:13457-13463 (Oct., 1987).
Linkhart et al., "Synthetic Peptide-Based Immunoassay for Amino-Terminal Propeptide of Type I Procollagen; Application for Evaluation of Bone Formation," Clin. Chem., 39:2254-2258 (1993).
Carey et al. "Radioimmunoassay for Type I Procollagen in Growth Hormone-deficient Children Before and During Treatment with Growth Hormone", Pediatric Res. 19:8-11 (1985).
Goldberg et al., "The Carboxyl Fragment Released by Bacterial Collagenase from Human Type I Procollagen: Antibodies to the Propeptide Determinants", Collagen Rel. Res. 5:393-404 (1985).
Melkko et al., "Radioimmunoassay of the Carboxyterminal Propeptide of Human I Procollagen", Clinical Chem. 36:1328-1332 (1990).
Fouser et al., "Feedback Regulation of Collagen Gene Expression: A Trojan Horse Approach", Proc. Natl. Acad. Sci. USA 88:10158-10162 (Nov., 1991).
Ebeling et al. "Utility of Type I Procollagen Propeptide Assays for Assessing Abnormalities in Metabolic Bone Diseases," J. Bone & Min. Res. 7:1243-1250 (Nov. 11, 1992).

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