Process for preparing N-cyanoguanidines

Details Process for preparing N-cyanoguanidines Process for preparing N-cyanoguanidines

1975-08-20

1977-09-20

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602948G, 260296AE, 260296R, 2603068R, 2603068D, 2603068A, 260307R, 260307H, 260308R, 260308H, 548337, C07D23364, C07D27738, C07D24908, C07D21194, C07D21196, C07D21182, C07D26108, C07D26332

Patent

active

040496716

ABSTRACT:
Process for preparing N-cyanoguanidines by treating N-(loweralkyl)-N'-cyano-isothioureas with an amine and a heavy metal salt. A specific product is N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine , useful as a histamine H.sub.2 -antagonist.

REFERENCES:
patent: 3876647 (1975-04-01), Durant et al.
patent: 3897444 (1975-07-01), Durant et al.

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