Prostacyclin (PGI.sub.2) analogues

Details Prostacyclin (PGI.sub.2) analogues Prostacyclin (PGI.sub.2) analogues

1987-03-13

1989-04-11

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548468, C07D20952

Patent

active

048208361

ABSTRACT:
Prostacyclin (PGI.sub.2) analogues represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is alkynyl; R.sub.3 and R.sub.4 each is hydrogen; R.sub.5 is straight or branched alkyl which may be substituted with heterocycle, straight or branched alkynyl, or cycloalkyl; the wavy line indicates R- or S-configuration, or their mixture; or a salt thereof being used as antithrombotic and antiulcer drugs.

REFERENCES:
patent: 4371542 (1983-02-01), Beck
patent: 4487960 (1984-12-01), Lin
patent: 4588823 (1986-05-01), Aristoff

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