Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl c

Details Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl c Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl c

1982-05-03

1984-04-03

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549417, C07D30930, C07D30910

Patent

active

044409273

ABSTRACT:
Totally synthetic analogs of the known inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, compactin and mevinolin, are prepared from a chiral synthon derived from D-glucose which has the same chirality as the natural products.

REFERENCES:
patent: 3901921 (1975-08-01), Urry et al.
patent: 4198425 (1980-04-01), Mitsui et al.
patent: 4255444 (1981-03-01), Oka et al.
patent: 4282155 (1981-08-01), Smith et al.
patent: 4375475 (1983-03-01), Willard et al.
Buehler et al., Survey of Organic Syntheses, vol. 2, pp. 99-100 and 16; vol. 1, p. 182.

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