Process for preparing 3-substituted-6-substituted-7-oxo-1-azabic

Details Process for preparing 3-substituted-6-substituted-7-oxo-1-azabic Process for preparing 3-substituted-6-substituted-7-oxo-1-azabic

1985-10-15

1989-04-11

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540310, C07D48404, A61K 3140

Patent

active

048208175

ABSTRACT:
Disclosed is a process for preparing 3-substituted-thio-6-(1'-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene -2-carboxylic acids (I) ##STR1## wherein X is a leaving group such as chloro, bromo, tosyl, mesyl or the like; and R.sup.8 is, inter alia, selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. The compounds I as well as their pharmaceutically acceptable O- and carboxyl derivatives are useful as antibiotics.

REFERENCES:
patent: 3033975 (1962-05-01), Nutting et al.
patent: 4013648 (1977-03-01), Horning et al.
patent: 4123528 (1978-10-01), Cama et al.
patent: 4552873 (1985-11-01), Miyadza et al.
Morrison et al., Organic Chemistry, p. 467 (1969).
Theilheimer, Synthetic Methods, vol. 11, p. 496, vol. 18, 681.
Wagner et al., Synthetic Organic Chemistry, pp. 787-788 (1953).

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