Method of preventing or reducing platelet loss during extracorpo

Details Method of preventing or reducing platelet loss during extracorpo Method of preventing or reducing platelet loss during extracorpo

1988-03-07

1989-04-11

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 3116

Patent

active

048207330

ABSTRACT:
A method is provided for preventing or reducing platelet loss during extracorporeal circulation, such as during coronary artery bypass or graft surgery by administering a thromboxane A.sub.2 antagonist alone or with prostacyclin and/or a prostacyclin mimic.

REFERENCES:
Ogletree, M. L., "Overview of Physiological and Pathophysiological Effects of Thromboxane A.sub.2," Red. Proc. 46:133, 1987.
Wonder, T., et al, "Preservation of Platelet Number and Function During Extracorporeal Membrane Oxygenation (ECMO) by Regional Infusion of PGI.sub.2," Circulation 58:II-207, 1978.
Addonizio, V. P., et al, "Thromboxane Synthesis and Platelet Secretion During Cardiopulmonary Bypass with Bubble Oxygenator," J. Thorac. Cardiovasc. Surg. 79:91, 1980.
Teoh, Kevin H., et al., "Cardiac Release of Prostacyclin and Thromboxane A.sub.2 During Coronary Revascularization," J. Thorac. Cardiovasc. Surg. 1987; 93:120-6.
Vinten-Johansen, Jakob, et al., "Studies of Controlled Reperfusion after Ischemia, V Superiority of Surgical Versus Medical Reperfusion after Regional Ischemia," J. Thorac. Cardiovasc. Surg. 1986, 92:525-534.

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