Methods for use in the mass analysis of chemical samples

Details Methods for use in the mass analysis of chemical samples Methods for use in the mass analysis of chemical samples

1985-08-21

1989-04-11

Richman, Barry S.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Amino acid or sequencing procedure

250288, 436173, G01N 128, G01N 2400

Patent

active

048206482

ABSTRACT:
A probe and method for using the same for supporting a sample in an ion source of a mass spectrometer comprises a target formed by a receptacle for a liquid sample in which the sample passes by diffusion to the high vacuum side of a semipermeable membrane and/or in which the sample is held as a droplet by surface tension. In order to replenish the droplet surface, the supply can be arranged to overflow the receptacle.

REFERENCES:
patent: 4239967 (1980-12-01), Carr et al.
patent: 4267457 (1981-05-01), Nakagawa et al.
Caprioli et al.; Fast Atom Bombardment for Real-Time Analysis of Peptide Fragments From Protein Digestions; Ca98(9):67824p, 1983.
Van Nostrand's Encyclopedia 5th edition, 1976, p. 422.
Self & Parente, "The Combined Use of Enzymatic Hydrolysis . . . Peptide Sequencing", vol. 10, No. 2, pp. 78-82.
Brodbelt & Cooks, "An Exceedingly Simple Mass Spectrometer Interface . . . Analysis", 57, pp. 1155-1157.
Hong et al., "Simultaneous Analysis of C-Terminal Amino Acid . . . Digestion", vol. 10, No. 8, 450-457.
Aimoto et al., "Amino Acid Sequence of a Heat-Stable Enterotoxin . . . Coli", 129, pp. 257-263.
Caprioli et al., "Performance of a Fast Atom Brombardment Source . . . Mass Spectrometer", vol. 10, No. 2, pp. 94-97.
Bradley et al., "Peptide Sequencing Using the Combination of Edman . . . Mass Spectrometry", vol. 104, No. 4, pp. 1223-1230.
Caprioli et al., "Fast Atom Bombardment For Real-Time Analysis of Peptide Fragments . . .", 46, pp. 419-422.
Smith & Caprioli, "Following Enzyme Catalysis . . . Mass Spectrometer", vol. 10, No. 2, pp. 98-102.

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