Process for the preparation of nitrosourea compounds

Details Process for the preparation of nitrosourea compounds Process for the preparation of nitrosourea compounds

1998-09-11

2000-08-01

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C27568

Patent

active

060969237

ABSTRACT:
A process for the preparation of a nitrosourea derivative, in particular 1,2-bis(2-chloroethyl)-1-nitrosourea, comprises reacting a non-nitrosated urea derivative with a metal nitrite in a two-phase solvent system comprising an aqueous acid and a non-miscible organic solvent.

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Lown et al, J.C.S. Chem. Comm., pp 675-676, 1981.
Kim et al, Arch. Pharm. Res., vol. 20, No. 3, pp 259-263, 1997.
Chemical Abstracts XP0020884888, 1974.

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