Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From carboxylic acid or derivative thereof
Patent
1986-08-01
1988-07-12
Anderson, Harold D.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
From carboxylic acid or derivative thereof
424 78, 528206, 528207, C08G 6300
Patent
active
047571284
ABSTRACT:
High molecular weight polyanhydrides, defined as polyanhydrides having a molecular weight average greater than 20,000 or an intrinsic viscosity of greater than 0.3 dl/g in an organic solvent at room temperature, are formed by melt polycondensation of highly pure isolated prepolymers under optimized reaction conditions, particularly time and temperature with removal of the condensation product. Higher molecular weights are obtained by inclusion of a catalyst with the prepolymers in the melt polymerization. Catalysts used for transterification, ring opening polymerization and related polymerizations may be utilized.
The high molecular weight polyanhydrides have improved physico-mechanical properties and are especially well suited for biomedical applications, particularly in controlled release devices for drug delivery.
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P. D'Amore, M. Marletta, and R. Langer in J. Biomed. Mtls. Res. 20, 51-64 (1986).
"Bioerodible Polyanhydrides for Controlled Drug Delivery," by H. B. Rosen, J. Chang, G. E. Wnek, R. J. Linhardt, and R. Langer in Biomaterials 4, 131-133 (1983).
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"Bioerodible Polyanhydrides as Drug-carrier Matrices. II: Biocompatibility and Chemical Reactivity," by K. W. Leong, Synthesis of Polyanhydrides. XII., N. Yoda, J. Polymer Sci. vol. 1, 1323-1338 (1963).
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Domb Abraham J.
Langer Robert S.
Anderson Harold D.
Massachusetts Institute of Technology
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