Drugs for topical application of sex steroids in the treatment o

Details Drugs for topical application of sex steroids in the treatment o Drugs for topical application of sex steroids in the treatment o

1998-12-10

2000-08-01

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514169, 514177, 514178, 514912, 514914, A61K 3156

Patent

active

060967331

ABSTRACT:
A topical drug application for the alleviation of kerato-conjunctivitis sicca (dry eye syndrome) is comprised of a solution of 17-.beta.-estradiol suspended or dissolved in a vehicle, and the method of preparation and application of the same. In the preferred embodiments, 17-.beta.-estradiol is in a lipid vehicle or 17-.beta.-estradiol 3-phosphate disodium dissolved in an aqueous vehicle having a pH of between about 6 to about 8. This invention may also be useful in treating other conditions where KCS may occur, such as post-operative corneal transplant patients and patients who cannot receive replacement estrogen therapy.

REFERENCES:
patent: 4642305 (1987-02-01), Johansson et al.
patent: 4774236 (1988-09-01), Cook et al.
patent: 4861763 (1989-08-01), Cook et al.
patent: 4866049 (1989-09-01), Maumenee et al.
patent: 5041434 (1991-08-01), Lubkin
Ostrogen-Therapie in Keratokonjunktivitis Sicca, Dr. J. Akramian et al., Spektrum der Augenheilkunde (Spektrum Augenheilkd.) Nov. 5, 1997 (195-97).
Olige Estradio-Hemihydrat-Augentropfen 0.025 Prozent; Fischer, H and Reimann H., Neues Rezeptur-Formularium (NRF) Pharmazeutisches Laboratorium, Pharmazeutische Zeitung (Pharm. Ztg.) Jan. 14, 1999 144/2 (38-40).
Benitez del Castillo, J.M.E, et al., "ffects of Estrogen Use on Lens Transmittance in Postmenopausal Women," Ophthalmology 1997; 104:970-973.
Sator, M.O., et al., "Treatment of menopausal keratoconjunctivitis sicca with topical oestradiol," Br. J. Obstet. Gyn. 1998; 105:100-102.

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