Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-07-02
2000-08-01
Lee, Howard C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 514 62, 4241371, A61K 3170
Patent
active
060967250
ABSTRACT:
The invention relates to methods for attenuating xenograft rejection in humans and old world monkeys, using oligosaccharides containing a Gal.alpha.1-3Gal motif, to neutralize or remove anti-.alpha.Gal antibodies. The invention additionally relates to methods for site directed activation of the complement cascade or host leukocytes using oligosaccharides containing a Gal.alpha.1-3Gal motif to target anti-.alpha.Gal antibodies. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention. Such compositions contain, as the active ingredient, an oligosaccharide containing a Gal.alpha.1-3Gal motif effective in binding anti-.alpha.Gal antibodies in vivo or ex vivo.
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McGuire Edward J.
Simon Paul M.
Lee Howard C.
Neose Technologies, Inc.
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