Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1998-02-03
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530380, 20415768, 20415715, 2041576, 514 21, A61K 3514, C07G 300
Patent
active
057145849
ABSTRACT:
The present invention relates to artificial blood and blood substitutes and supplements made by a process for cross-linking a proteinaceous material including an oxygen transport/binding protein such as hemoglobin, methhemoglobin, myoglobin and hemocyanin. The process comprises: i) soaking the proteinaceous material including the oxygen transport/binding protein to be cross-linked in an aqueous solution of high osmolality; ii) incubating the material in an aqueous buffer including an amount of a photooxidative catalyst sufficient to catalyze photooxidation of the material; and iii) irradiating the material and the catalyst of step (i) with light that includes a range of wavelengths selectively absorbed by the catalyst. Irradiation is effected under conditions such that cross-linking of the material occurs.
REFERENCES:
patent: 5147514 (1992-09-01), Mechanic
Ginotti et al, Photochemistry and Photobiology, vol. 29, pp. 1119-1125, 1979.
Girotti, Albert W., Lyman, Suzanne and Deziel, Mark R., "Methylene Blue-Sensitized Photooxidation of Hemoglobin: Evidence for Cross-Link Formation," Photochemistry and Photobiology, vol. 29, pp. 1119-1125 (Great Britain, 1979).
Mohamed Abdel A.
Tsang Cecilia J.
Wisner Mark R.
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