Antimicrobial peptides

Details Antimicrobial peptides Antimicrobial peptides

1997-01-24

1998-02-03

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530326, 530327, 514 2, 514 12, 514 13, 514 14, A61K 3816, C07K 1400

Patent

active

057145776

ABSTRACT:
The invention is directed to antimicrobial peptides which correspond in sequence to selective amino acid sequences in viral transmembrane proteins. In particular, the proteins are derived from lentiviruses, primarily HIV and SIV. The peptides comprise arginine-rich sequences, which, when modeled for secondary structure, display a high amphipathicity and hydrophobic moment. They are highly inhibitory to microorganisms, while being significantly less active in regard to mammalian cells. As a result, the peptides of the invention may be defined as selective antimicrobial agents. The invention is also directed to antimicrobial peptides which are structural and functional analogs and homologs of the peptides and which exhibit selective inhibitory activity towards microorganisms. The invention is also directed to pharmaceutical compositions comprising the antimicrobial peptides of the invention and to methods for their use in inhibiting microbial growth and treatment of microbial infections.

REFERENCES:
Miller et al., AIDS Res. Hum. Retroviruses 9:1057, 1993.
Miller et al., AIDS Res. Hum. Retroviruses 7:511, 1991.
Srinivas et al., J. Biol. Chem. 267:7121, 1992.
Arroyo et al., J. Virol. 69:4095, 1995.
Tencza et al., AIDS Res. Hum. Retroviruses 13:263, 1997.
Zhong et al. Int. J. Pept. Prot. Res., 45:337, 1995.
Srinivas et al., J. Biol. Chem. 268:22895, 1993.
Chernomordik et al., J. Virol. 68:7115, 1994.
Gawrish et al., Biochemistry 32:3112, 1993.
Srinivas et al., AIDS Res. Hum. Retroviruses 10:1489, 1994.
Tencza et al., J. Virol. 69:5199, 1995.
Rushlow et al., Virology 155:309, 1986.
Habermann et al., Science 177:314, 1972.
Miller et al., Virology 196:89, 1993.
Fontenot et al., Peptide Research 45:19, 1991.
Zhang et al., Proc. Natl. Acad. Sci. USA 93:12519, 1996.
Yuan et al., Biochemistry 34:10690, 1995.
Venable et al., AIDS Res. Hum. Retroviruses 5:7, 1989.
Garnier et al., J. Mol. Biol. 120:97, 1978.
Eisenberg et al., Proc. Natl. Acad. Sci. U.S.A. 81:140, 1984.
Wild et al., Proc. Natl. Acad. Sci. USA 89:10537, 1992.
Moore et al., Peptide Research 7:265, 1994.
Chou et al., Biochemistry 13:222, 1974.
Eisenberg et al., J. Mol. Biol. 179:125, 1984.
Lehrer et al., Infect. Immun. 42:10, 1983.
Pearson et al., Antimicrob. Agents Chemother. 18:699, 1980.
Fujii et al., Protein Sci. 1:1454, 1992.
Eisenberg et al., Biopolymers 29:171, 1990.
Chernomordik, A. et al., An Amphipathic Peptide from the C-Terminal Region of the HIV Envelope Glycoprotein Causes Pore Formation in Membranes, J. Virol. 68, 7115-7123 (1994). see entire article.
Gawrisch et al., Interaction of Peptide Fragment 828-848 of the Envlope Glycoprotein of HIV with Lipid Bilayers, Biochemistry 32, 3112-3118 (1993). see entire article.
Koenig, B. et al., Effect of the conformation of a peptide from gp41 on binding and domain formation in model membranes, Mol. Membrane Biol. 12, 77-82 (1995). see entire article.
Ward, N. et al., Inhibition of protein kinase C by a synthetic peptide, Cancer Lett. 88, 37-40 (1995). see entire article.

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