Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-04-18
1998-02-03
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514290, 546 93, 546203, A61K 3445, C07D21120
Patent
active
057145016
ABSTRACT:
A piperidine derivative of formula (1) or salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 independently represent H or together represent O, R.sup.3 represents H, --R.sup.5 --COOR.sup.6, or --COOR.sup.6 (wherein R.sup.5 is a lower alkylene group, --CONH--, or --CONHCH.sub.2, and R.sup.6 is H or a lower alkyl group), R.sup.4 represents H, an aralkyloxy carbonyl group, an aminomethyl carbonyl group, or an aralkyloxy carbonyl aminomethyl carbonyl group, A represents O or a double bond, and the broken line has the meaning that a bonding hand may be present; and preventive and therapeutic agents for allergies, antihistaminic agents, and antileucotriene agents comprising the derivative or salts as their effective component.
The compound of formula (1) has excellent antihistaminic activities and antileukotriene activities, which are well balanced, and is useful as a drug for the prevention and treatment of allergies such as asthma, allergic rhinitis, allergic dermatosis and urticaria.
REFERENCES:
patent: 4282233 (1981-08-01), Vilani
patent: 4356184 (1982-10-01), Deason
patent: 4863931 (1989-09-01), Schumacher
patent: 5151423 (1992-09-01), Piwinski et al.
patent: 5464840 (1995-11-01), Ting et al.
patent: 5508280 (1996-04-01), Hibert et al.
Timmerman Henk
Zhang Mingqiang
Chang Ceila
Kowa Co. Ltd.
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