Protein activator of apoptosis

Details Protein activator of apoptosis Protein activator of apoptosis

1999-06-10

2000-08-01

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 231, 536 235, 536 243, 536 2431, 536 2433, 435 6, 4353201, C12N 1563, C12N 1585, C12N 1586, C07H 2104, C07H 2102

Patent

active

060965398

ABSTRACT:
An isolated and purified human protein activator of apoptosis is described. A cDNA sequence which encodes the native kinase of death is disclosed as well as the structural coding region and the amino acid residue sequence. Methods are provided which employ the sequences to identify compounds that modulate the biological and/or pharmacological activity of the activator and hence regulate apoptosis. Biologically-effective antisense molecules, as well as dominant negative mutant versions of the apoptosis activator are described which are suitable for therapeutic use. The invention is also drawn toward the study, prevention, diagnosis, and treatment of pathophysiological disorders related to apoptosis.

REFERENCES:
M. Kelliher et al., "The Death Domain Kinase RIP Mediates the TNF-Induced NF-kB Signal", Immunity, vol. 8, pp. 297-303, Mar., 1998.
B. Stanger et al. "RIP: A Novel Protein Containing a Death Domain That Interacts with Fas/APO-1 (CD95) in Yeast and Causes Cell Death", Cell, vol. 81, pp. 513-523, may 19, 1995.
Y. Jiang et al., "Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains", Science, vol. 283, pp. 543-546, Jan. 22, 1999.
M. Cardone et al., "Regulation of Cell Death Protease Caspase-9 by Phosphorylation", Science, vol. 282, pp. 1318-1321, Nov. 13, 1998.
L. Miller et al., "Apoptosis", Science, vol. 281, p. 1301, Aug. 28, 1998.
M. Barinaga, "Stroke-Damaged Neurons May Commit cellular Suicide", Science, vol. 281, pp. 1302-1304, Aug. 28, 1998.
A. Ashkenazi et al., "Death Receptors: Signaling and Modulation", Science, vol. 281, pp. 1305-1308, Aug. 28, 1998.
D. Green et al., "Mitochondria and Apoptosis", Science, vol. 281,, pp. 1309-1316, Aug. 28, 1998.
N. A. Thornberry et al., "Caspases: Enemies Within", Science, vol. 281, pp. 1312-1316, Aug. 28, 1998.
G. Evan et al., "A Matter of Life and Cell Death", Science, vol. 281, pp. 1321-1326, Aug. 28, 1998.
J.M. Adams et al., "The Bcl-2 Protein Family: Arbiters of Cell Survival", Science, vol. 281, pp. 1322-1326, Aug. 28, 1998.
M. Hengartner et al., "Death by Crowd Control", Science, vol. 281, pp. 1298-1299, Aug 28, 1998.
X. Yang et al., "Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis", Science, vol. 281, pp. 1355-1357, Aug. 28, 1998.
X. Sun et al., "RIP3, a novel Apoptosis-inducing Kinase", The Journal of Biological Chemistry, vol. 274, No. 24, Issue of Jun. 11, pp. 16871-16875, 1999.

Affiliated with

Also associated with

Rating

Protein activator of apoptosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein activator of apoptosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein activator of apoptosis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-662600