Liquisolid systems and methods of preparing same

Details Liquisolid systems and methods of preparing same Liquisolid systems and methods of preparing same

1998-08-19

2000-08-01

Krass, Frederick

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424457, 424458, 424459, 424461, 424462, 424464, 424465, 424468, 424489, 424490, 424493, 424494, 424497, 424501, 264 5, 264 6, 264 7, 264 404, A61K 948

Patent

active

060963379

ABSTRACT:
Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liduid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable non-volatile solvents, may be converted into free-flowing and readily compressible powders by a simple admixture with selected powder excipients referred to as the carrier and coating materials. Various grades of microcrystalline or amorphous cellulose may be used as carriers, whereas very fine particle size silica powders may be used as coating materials.

REFERENCES:
"Powdered Solution Technolgy: Principles and Mechanism", Spireas et al., Pharmaceutical Research, vol. 9, No. 10, 1992.
Powdered Solution Technology: Principles and Mechanism, Pharm Res. 9:1351-1368, 1992.
Use of Powdered Solutions to Improve the Dissolution Rater of Polythiazide Tablets, Drug Dev. Ind. Pharm. 16:769-777, 1990.

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