Chemistry: analytical and immunological testing – Oxygen containing – Hydroxyl containing
Patent
1992-04-21
1993-02-02
Rosen, Sam
Chemistry: analytical and immunological testing
Oxygen containing
Hydroxyl containing
436811, 436822, G01N 3300, G01N 3349, G01N 33493
Patent
active
051837641
ABSTRACT:
An enhanced quantitative assay for chiro-inositol concentration can be used to determine insulin-resistance, or a predeposition to the development of insulin-resistance, in type I and type II diabetics. Spot urine or serum samples reflecting concentrations of chiro-inositol below about 1.0 micrograms/ml in urine or 0.1 micrograms/ml in serum are indicative of a predisposition to the development of insulin-resistance, while concentrations below about 0.3 micrograms/ml or 0.03 micrograms/ml in serum are associated with actual insulin-resistance symptoms. The assay can be employed for patient diagnosis, insulin therapy monitoring, and family screening.
REFERENCES:
Williamson et al.-Chem. Abst., vol. 105 (1986), p. 18407j.
Kennington et al., "Low Urinary Chiro-Inositol Excretion in Non-Insulin-Dependent Diabetes Mellitus", N. Eng. J. Med., Aug. 9, 1990, pp. 373-378, vol. 323.
Romero et al., "Anti-Inositol Antibodies Selectively Block Some of the Actions of Insulin in Intack BC.sub.3 H1 Cells", Proc. Natl. Acad. Sci. USA., vol. 87, pp. 1476-1480, Feb. 1990.
Kennington Alison S.
Larner Joseph
Rosen Sam
University of Virginia Alumni Patents Foundation
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