Composition for causing skin lightening

Details Composition for causing skin lightening Composition for causing skin lightening

1999-03-05

2000-08-01

Spear, James M.

Drug, bio-affecting and body treating compositions

Bleach for live hair or skin

424 59, 4241951, 424401, A61K 742, A61K 748

Patent

active

06096295&

ABSTRACT:
A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof, or effective .alpha..sub.2 -antagonists to skin for inhibiting melanogenesis in the skin leading to skin lightening. The yohimbine may be provided as a natural extract, for example, as an extract of Johimbe bark. The composition may include a skin exfoliant.

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Morishita, F.; "Responses of the Melanophores of the Medaka, Oryzias latipes, To Adrenergic Drugs: Evidence for Involvement of Alpha.sub.2, Adrenergic Receptors Mediating Melanin Aggregation", Comp. Biochem. Physiol., 88C (1) :69-74, 1987.
Abstract, Database WPI, Week 9549, Derwent Publications Ltd., London, GB; AN 379974, XP002094296 & JP 07 258068 A (KAO) Oct, 9, 1995.

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