Method and compositions for increasing the serum half-life of ph

Details Method and compositions for increasing the serum half-life of ph Method and compositions for increasing the serum half-life of ph

1996-06-13

1998-02-03

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 854, 514 11, 514 16, 514262, 514274, 514335, 514368, 514421, 514423, 514460, 514471, 514567, 514568, 514571, 514620, 514626, 514737, 514772, 514776, A61K 4748

Patent

active

057141428

ABSTRACT:
Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active agent and a transthyretin-binding ligand such as tetraiiodothyroacetic acid, 2,4,6-triiodophenol, flufenamic acid, or the like.

REFERENCES:
patent: 5068227 (1991-11-01), Weinshenker
patent: 5273885 (1993-12-01), Visor et al.
Bickel et al., "Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery," Proc. Natl. Acad. Sci., USA 90:2618-2622 (1993).
Brouwer et al., "Competitive inhibition of thyroxine binding to transthyretin by monohydroxy metabolites of 3,4,3',4'-tetrachlorobiphenyl," Chemosphere 20(7-9):1257-1262 (1990).
Cavalieri et al., "The effects of drugs on the distribution and metabolism of thyroid hormones," Pharmacological Reviews 33(2):55-80 (1981).
Divino et al., "Receptor-mediated uptake and internalization of transthyretin," J. Biol. Chem. 265(3):1425-1429 (1990).
Divino et al., "Transthyretin Receptors on Human Astrocytoma Cells," J. Clin. Endocrin. Metab. 71(5):1265-1268 (1990).
Edgington et al., "The anatomy of access: Peptide drug delivery," Bio/Technology 9:1327-1331 (Dec. 1991).
Leamon et al., "Delivery of macromolecules into living cells: A method that exploits folate receptor endocytosis," Proc. Natl. Acad. Sci., USA 88:5572-5576 (1991).
Mao et al., "Superoxide dismutase: Improving its pharmacological properties by conjugation with human serum albumin," Biomat., Art. Cells, Art. Org. 17:229-244 (1989).
Munro et al., "Drug competition for thyroxine binding to transthyretin (prealbumin): Comparison with effects on thyroxine-binding globulin," J. Clin. Endocrin. Metabol. 68(6):1141-1147 (1989).
Ogino, "Chemical modification of superoxide dismutase," Int. J. Peptide Protein Res. 32:153-159 (1988).
Van Den Berg, "Interaction of chlorinated phenols with thyroxine binding sites of human transthyretin, albumin and thyroid binding globulin," Chem.-Biol. Interactions 76:63-75 (1990).
Arano et al., "A Novel Bifunctional Metabolizable Linker for the Conjugation of Antibodies with Radionuclides," Bioconjugate Chem. 2:71-76 (1991).
Bank, "Effects of Polyhalogenated Aromatic Hydrocarbons on Vitamin A Catabolism and the Regulation of Vitamin A Homeostatis in Rats (Hydrocarbons)," Database: Dissertation Abstracts AN:AAI9013852 (1989).
Bhattacharya et al., "Homogeneous Enzyme Immunoassay of Thyroxine and Triiodothyronine Using Glucose-6-phosphate Dehydrogenase and Horse Radish Peroxidase," Indian Journal of Experimental Biology 26:990-992 (1988).
Blondeau et al., "Characterization of the Thyroid Hormone Transport System of Isolated Hepatocytes," The Journal of Biological Chemistry 263(6):2685-2692 (1988).
Busche et al., "Preparation and Utility of a Radioiodinated Analogue of Daunomycin in the Study of Multidrug Resistance," Mol. Pharmacol. 35(4): 414-421 (1989).
McKinney et al., "Molecular Interactions of Toxic Chlorinated Dibenzo-p-dioxins and Dibenzofurans with Thyroxine Binding Prealbumin," J. Med. Chem. 28:375-381 (1985).
Melhus, "Studies of the Vitamin A Transporting Protein Complex Retinol-Binding Protein--Transthyretin," Database: Dissertation Abstracts AN: AAIC220221 (1990).
Nichols, "Molecular Genetic Studies of Autosomal Dominant, Systemic Amyloidosis (Amyloidosis)," Database: Disssertation Abstracts AN: AAI9020740 (1989).
Place et al., "A Colorimetric Immunoassay Based on an Enzyme Inhibitor Method," J. Immunol. Methods 61(2):209-216 (1983).
van den Berg et al., "A New Radioimmunoassay for the Determiniation of the Angiotensin-converting Enzyme Inhibitor Perindopril and its Active Metabolite in Plasma and Urine: Advantages of a Lysine Derivative as Immunogen to Improve the Assay Specificity," J. Pharm. Biomed. Anal. 9(7):517-524 (1991).

Affiliated with

Also associated with

Rating

Method and compositions for increasing the serum half-life of ph does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and compositions for increasing the serum half-life of ph, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and compositions for increasing the serum half-life of ph will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-659915