Preparation of substituted 2-chloropyridines

Details Preparation of substituted 2-chloropyridines Preparation of substituted 2-chloropyridines

1992-06-24

1994-08-02

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546168, 546169, 546170, 546283, 546286, 546287, 546323, 546326, C07D21326, C07D21361, C07D21356, C07D21381

Patent

active

053347242

ABSTRACT:
A process for the preparation of a substituted 2-chloropyridine derivatives of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent hydrogen or various other radicals, which comprises reacting a pyridine-1-oxide of the formula ##STR2## with an aromatic carbonyl chloride in the presence of an inert organic solvent and in the presence of an acid acceptor at a temperature between about -20.degree. C. and 200.degree. C.

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H. Yamanaka et al., "Site-Selectivity in the Reaction of S-Substituted . . . ", Chem. Pharm. Bull. (1988) vol. 36, pp. 2244-2247.
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