Monoclonal antibody (D612) having selective reactivity for gastr

Details Monoclonal antibody (D612) having selective reactivity for gastr Monoclonal antibody (D612) having selective reactivity for gastr

1991-06-18

1993-02-02

Doll, John J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7021, 4351722, 424 858, 424 8591, 5303888, 53038885, C12N 520, C07K 1528, A61K 39395

Patent

active

051837560

ABSTRACT:
The present invention relates to the monoclonal antibody (termed D612) having selective reactivity for gastrointestinal carcinoma and methods for employing the same. A hybridoma producing such antibodies has been prepared.

REFERENCES:
patent: 4579827 (1986-04-01), Sakamoto
Herlyn, Proc Natl. Acad. Sci., (Mar. 1979), vol. 76(3):1438-42.
Sears, The Lancet, (1982), pp. 762-765.
Fersten et al., Characterization of the Colorectal Carcinoma-associated Antigen Defined by Monoclonal Antibody D612, Cancer Research. vol. 51, pp. 926-934 (1991).
Gottlinger et al., The Epithelial Cell Surface Antigen 17-1A, A Target for Antibody-Mediated Tumor Therapy: Its Biochemical Nature, Tissue Distribution and Recognition by Different Monoclonal Antibodies, Int. J. Cancer: vol. 38, pp. 47-53 (1986).
Pendurthi, et al.; submitted to Int. J. Cancer; Lymphokine-Activated Killer Cell Cytotoxicity Against Human Colon Carcinomas Enhanced by Monoclonal Antibody D612; Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Md.
Pendurthi, et al.; submitted to J. Biol. Res. Mod.; Human Lymphokine-Activated Killer Cells Augment Immunotherapy of Human Colon Carcinoma Xenografts with Monoclonal Antibody D612.
Muraro, et al.; In. J. Cancer: 43, 598-607; A Monomclona Antibody *D612) With Selective Reactivity For Malignant And Normal Gastro-Intestinal Epithelium.

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