Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1992-01-30
1994-08-02
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530829, 424529, 424530, 424533, A61K 3514, A61K 3700
Patent
active
053347064
ABSTRACT:
This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase perfusion, up to a dose of about 2500 mg per kilogram of body weight.
REFERENCES:
patent: 3991181 (1976-11-01), Doczi
patent: 4529719 (1985-07-01), Tye
patent: 4532130 (1985-07-01), Djordjevich et al.
patent: 4988515 (1991-01-01), Buckberg
Amberson, W. R. et al., "On Use of Ringer-Locke Solutions Containing Hemoglobin as a Substitute for Normal Blood in Mammals," J Cell Comp Physiol, 5:359 (1934).
Amberson, W. R. et al., "Clinical Experienced with Hemoglobin-Saline Solutions" J Appl Physiol, 1:469 (1949).
Birndorf, N. I. et al., :"Effect of Red Cell stroma-Free Hemoglobin Solution on Renal Function in Monkeys" J Appl Physiol, 29:573 (1970).
Biro, G. P. et al., "The Effect of Hemodilution with Stroma-Free Hemoglobin and Dextran on Collateral Perfusion of Ischemic Myocardium in the Dog" Am Hrt J, 99:64 (1980).
Buttle, G. A. H. et al., "Blood Substitutes in Treatment of Acute Hemorrhage" Lancet, 2:507 (1940).
Elia, E. et al., "Stroma-Free Hemolgobin in the Resuscitation of Hemorrhagic Shock" Surg Forum, 25:201 (1974).
Feola, M. et al., "Improved Oxygenation of Ischemic Myocardium by Hemodilution with Stroma-Free Hemoglobin Solution" Chest, 75:369 (1979).
Feola, M. et al., "Toxicity of Polymerized Hemoglobin Solutions" Surg Gynecol Obstet, 166:211 (1988).
Jan, K. M. et al., "Coronary Hemodynamics and Oxygen Utilization after Hematocrit Variations in Hemorrhage" Am J Physiol, 239:H326 (1980).
Jesch, F. H. et al., "Oxygen-Transporting Fluids and Oxygen Delivery with Hemodilution" Crit Care Med, 10:270 (1982).
Keipert, P. E. et al., "Pyridoxylated Polyhemoglobin as a Red cell Substitute for Resuscitation of Lethal Hemorrhagic Shock in Conscious Rats" Biomater Med Devices Artif Organs, 13:1 (1985).
Maningas, P. A. et al., "Hypertonic Sodium Chloride Solutions for the Prehospital Management of Traumatic Hemorrhagic Shock:A Possible Improvement in the Standard of Care?" Ann Emerg Med, 15:1411 (1986).
Miller, J. H. et al., "The Effect of Hemoglobin in Renal Function in the Human" J. Clin Invest, 30:1033 (1951).
Moss, G. S. et al., "Transport of Oxygen and Carbon Dioxide by Hemoglobin-Saline Solution in the Red Cell Free Primate" Surg Gynecol Obstet, 142:357 (1976).
Peskin, W. P. et al., "Stroma-Free Hemoglobin Solution: The `Ideal` Blood Substitute?" Surgery, 66:185 (1969).
Prough, D. S. et al., "Effects of Hypertonic Saline Versus Lactated Ringer's Solution on Cerebral Oxygen Transport During Resuscitation from Hemorrhagic Shock" J. Neurosurg, 64:627 (1986).
Przybelski, R. J. et al., J Lab and Clin Med, 117:143 to 151 (1991).
Rabiner, S. F. et al., J Exp Med, 126:1127 to 1142 (1967).
Rabiner, S. F., "Hemoglobin Solution as a Plasma Expander" Fed Proc, 34:1454 (1975).
Relihan, M. et al., "Clearance Rate and Effect on Renal Function of Stroma-Free Hemoglobin Following Renal Ischemic" Ann Surg, 176:700 (1972).
Savitsky, J. P. et al., "A Clinical Safety Trial of Stroma-Free Hemoglobin" Clin Phamacol ther, 23:73 (1978).
Schmoker, J. D. et al., "Hypertonic Fluid Resuscitation Improves Cerebral Oxygen Delivery and reduces Intracarnial Pressure After Hemorrhagic Shock" J Trauma 31:1607 (1991).
Shoemarker, W. C. et al., "Resuscitation of the Trauma Patient; Resotration of Hemodynamic Functions Using Clinical Algorithms" Ann Emerg Med, 15:1437 (1986).
Wade, C. E. et al., "Superiority of Hypertonic Saline/Dextran over Hypertonic Saline During the First 30 Minutes of Resuscitation Following Hemorrhagic Hyoptension in Conscious Swine" Resuscitation, 20:49 (1990).
Barta Kent
Bates Sarah E.
Baxter International
Flattery Paul C.
Mohamed Abdel A.
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