Human RAD50 gene and methods of use thereof

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4353201, 536 235, 536 2431, 536 231, 935 9, C07H 2104, C12N 121, C12N 1563

Patent

active

059654279

ABSTRACT:
Substantially-isolated polynucleotides encoding human RAD50 polypeptides, human RAD50 genomic sequences, and methods of use thereof.

REFERENCES:
Genbank Loci: R92967; L46900; N70974; H93370; L43399; L42096.
Clonetech 1995 Catalog pp. 32, 80-81 and 96-97.
Alani, E. et al., "Analysis of Wild-Type and rad50 Mutants of Yeast Suggests and Intimate Relationship between Meiotic Chromosome Synapsis and Recombination," Cell. 61: 419-436 (1990).
Alani, E. et al., "The Yeast RAD50 Gene Encodes a Predicted 153-kD Protein Containing a Purine Nucleotide-Binding Domain and Two Large Heptad-Repeat Regions," Genetics. 122: 47-57 (1989).
Baumann, P. et al., "Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro," Cell. 87: 757-766 (1996).
Beckett, M.A. and Weichselbaum R.R., "Southern Analysis of Human Head and Neck Cancer Cells for Homologous Sequences Using Yeast Gamma Repair Genes," Journal of Surgical Oncology. 38: 257-260 (1988).
Benson, F.E. et al., "Purification and Characterization of the Human Rad51 Protein, an Analogue of E.coli RecA," The EMBO Journal. 13: 5764-5771 (1994).
Dolganov, G.M. et al., "Human Rad50 Is Physically Associated with Human Mrell: Identification of a Conserved Multiprotein Complex Implicated in Recombinational DNA Repair," Molecular and Cellular Biology. 16: 4832-4841 (1996).
Glassner, B.J. and Mortimer, R.K., "Synergistic Interactions between RAD5, RAD16 and RAD54, Three Partially Homologous Yeast DNA Repair Genes Each in a Different Repair Pathway," Radiation Research. 139: 24-33 (1994).
International Search Report for PCT Application No. PCT/US97/01299 (Sep. 15, 1997).
Raymond, W.E. and Kleckner, N., "Expression of the Saccharomyces cerevisiae RAD50 Gene During Meiosis: Steady-State Transcript Levels Rise and Fall While Steady-State Protein Levels Remain Constant," Mol Gen Genet. 238: 390-400 (1993).
Raymond, W.E. and Kleckner, N., "RAD50 Protein of S.cerevisiae Exhibits ATP-Dependent DNA Binding," Nucleic Acids Research. 21: 3851-3856 (1993).
Allan, G.J., et al., "Loss of Heterozygosity on Chromosome 5 in Sporadic Ovarian Carcinoma is a Late Event and is Not Associated with Mutations in APC at 5q21-22," Hum. Mutat. 3:283-291 (1994).
Barrett, M.T., et al., "Determination of the Frequency of Loss of Heterozygosity in Esophageal Adenocarcinoma by Cell Sorting, Whole Genome Amplification and Microsatellite Polymorphisms," Oncogene 12:1873-1878 (1996).
Hsieh, L.L., and Huang, Y.C., "Loss of Heterozygosity of APC/MCC Gene in Differentiated and Undifferentiated Gastric Carcinomas in Taiwan," Cancer Lett. 96:169-174 (1995).
Largey, J.S., et al., "Loss of Heterozygosity Involving the APC Gene in Oral Squamous Cell Carcinomas," Oral Surg. Oral Med. Oral Pathol. 77:260-263 (1994).
Li, H., et al., "[Multiple Tumor Suppressor Genes in Esophageal Carcinoma Induced in Human Fetus Esophageal Epithelium by NMBzA]," Chung Hua Chung Liu Tsa Chih 17:170-174 (1995) (abstract).
Li, H., and Lu, S., "[Mutation of Tumor Suppressor Genes APC and MCC in Human Esophageal Cancer,]" Chung Hua Chung Liu Tsa Chih 17:9-12 (1995) (abstract).
Medeiros, A.C., et al., "Loss of Heterozygosity Affecting the APC and MCC Genetic Loci in Patients with Primary Breast Carcinomas," Cancer Epidemiol. Biomarkers Prev. 3:331-333 (1994).
Miura, K., et al., "Deletion Mapping in Squamous Cell Carcinomas of the Esophagus Defines a Region Containing a Tumor Suppressor Gene Within a 4-Centimorgan Interval of the Distal Long Arm of Chromosome 9," Cancer Res. 55:1828-1830 (1995).
Montesano, R., et al., "Genetic Alterations in Esophageal Cancer and Their Relevance to Etiology and Pathogenesis: a Review," Int. J. Cancer 69:225-235 (1996).
Nakashima, H., et al., "Microsatellite Instability in Japanese Esophageal Carcinoma," Int. J. Cancer 64:286-289 (1995).
Ogasawara, S., et al., "Frequent Microsatellite Alterations on Chromosome 3p in Esophageal Squamous Cell Carcinoma," Cancer Res. 55:891-894 (1995).
Ogasawara, S., et al., "Common Deleted Region on the Long Arm of Chromosome 5 in Esophageal Carcinoma," Gastroenterology 110:52-57 (1996).
Pederson, B., "5q-: Pathogenetic Importance of the Common Deleted Region and Clinical Consequences of the Entire Deleted Segment," Anticancer Res. 13:1913-1916 (1993).
Schnitzler, M., et al., "Quantitation of APC mRNA in Human Tissues," Biochem. Biophys. Res. Commun. 217:385-392 (1995).
Tamura, G., et al., "Two Distinct Regions of Deletion on the Long Arm of Chromosome 5 in Differentiated Adenocarcinomas of the Stomach," Cancer Res. 56:612-615 (1996).
Tavassoli, M., et al., "Loss of Heterozygosity on Chromosome 5q in Ovarian Cancer is Frequently Accompanied by TP53 Mutation and Identifies a Tumour Suppressor Gene Locus at 5q13.1-21," Br. J. Cancer 74:115-119 (1996).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human RAD50 gene and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human RAD50 gene and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human RAD50 gene and methods of use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-651603

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.