Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-06
1999-10-12
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 4352523, 4353201, 530350, 536 237, 4242401, 4242541, C12P 2106, C12N 120, C07H 2104, C07K 100
Patent
active
059653850
ABSTRACT:
The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
REFERENCES:
Kaslow, H. and Bums, D. (1992), FASEB J. 6, 2684-2690.
Watkins, P. et al. (1984), J. Biol. Chem. 260, 13478-13482.
Lim, L.K. et al. (1985), J. Biol Chem. 260, 2585-2588.
Burns, D. and Manclark, C.C. 1986), J. Biol. Chem. 261. 4324-4327.
Moss, J., et al. (1986), Biochemistry 25, 2720-2725.
Armstrong, G., et al. (1988), J. Biol Chem. 263, 8677-8684.
Witvliet, M., et al. (1989), Infect. Immun. 57, 3324-3330.
Saukkonen, K., et al (1992), Proc. Natl Acad. Sci. U.S.A. 89, 118-122.
Oda, M, et al. (1984), J Infect. Dis. 150, 823-833.
Sato, H. and Sato, Y (1984), Infect. Immun. 46, 415-421.
Halperin, S., et al. (1991), J Infect. Dis. 163, 355-361.
Olin, P. (1991), Dev. Blot Stand. 73, 33-36.
Zealey, G., et al. (1992), Vaccine Research 1, 413-427.
Pizza, M., et al. (1989), Science 246, 497-499.
Loosmore, S., et al. (1990), Infect. Immun. 58, 3653-3662.
Locht, C. and Keith, J. (1986), Science 232, 1258-1264.
Cieplak, W., et al. (1988), Proc. Natl. Acad. Sci. USA 85, 4667-4671.
Burnette, W., et al. (1988), Science 242, 72-74.
Kaslow, H., et al. (1992), Vaccine Res. 1, 47-54.
Cockle, S. (1989), FEBS Letters 249, 329-332.
Lobet, Y., et al. (1993), J. Exp. Med. 177, 79-87.
Loosmore, S., et al. (1993), Infect. Immun. 61, 2316-2324.
Choe, S., et al. (1992), Nature 357, 216-222.
Allured, V., et al. (1986), Proc. Natl. Acad. Sci. U.S.A. 83, 1320-1324.
Brandhuber, B. et al. (1988) Proteins 3, 146-154.
Sixma, T., et al. (1991), Nature 351, 371-377.
Sixma, T., et al. (1993), J. Mol. Biol. 230, 890-918.
Sixma, T., et al. (1993), Biochemistry 32, 191-198.
Stein, P., et al. (1992), Nature 355, 748-750.
Wout, J. et al. (1992), Infect. Immun. 60, 3303-3308.
Graf. R. et al. (1992) Molec. Pharmacol., 42, 760-764.
Spangler, B., et al. (1988), International Workshop on Bordetella pertussis, Rocky Mountain Laboratories, Hamilton, Montana.
Raghavan, M., et al. (1990), J. Molec. Biol. 213, 411-414.
Sakabe, N. (1983), J. Appl. Crystallogr. 16, 542-547.
Higashi, T. (1989), J. Appl. Crystallogr. 22, 9-18.
Sheldrick, G. (1991), in Crystallographic Computing 5: From Chemistry to Biology (eds Moras, D., et al.) pp. 145-157 (Oxford University Press, Oxford).
Otwinowski, Z. (1991), in Isomorphous Replacement and Anomalous Scattering: Proceedings of the CCP4 Study Weekend Jan. 25-26, 1991 (eds Wolf, W., Evans, P. and Leslie, A.) pp. 80-86 (SERC, Daresbury Laboratory).
Colman, P. et al. (1976), in Crystallographic Computing Techniques (eds Ahmed, F., Huml, Y, and Sedlacek, B.) pp. 248-258 (Munksgaard, Copenhagen).
Read, R. and Schierbeek, K. (1988), J Appl. Crystallogr. 21, 490-495.
Podjarny, A. and Rees, B. (1991), in Crystallographic Computing 5: From Chemistry to Biology (eds Moras, D., Podjarny, A. and Thierry, J.) pp. 361-372 (Oxford University Press, Oxford).
Jones, T., et al. (1991), Acta Crystallogr. A47, 110-119.
Brunger, A., et al. (1987), Science 235, 458-460.
Read, R. (1986), Acta Crystallogr. A42, 140-149.
Loosmore, S., et al. (1989), Nucleic Acids Research 17, 8365.
Mooris, A., et al. (1992), Proteins 12, 345-364.
Kabsch, W. and Sander, C. (1983), Biopolymers 22, 2577-2637.
Pizza, M., et al. (1988), Proc. Natl. Acad. Sci. U.S.A. 85, 7521-7525.
Barbieri, J. and Cortina, G. (1988), Infect. Immun. 56, 1934-1941.
Janin, J., et al. (1988), J. Molec. Biol. 204, 155-164.
Krueger, K., et al. (1991), J. Biol. Chem. 266, 8122-8128.
Murzin, A., (1993), EMBO J. 12, 861-867.
Tamura, M., et al. (1982), Biochemistry 21, 5516-5522.
Weis, W., et al. (1991), Science 254, 1608-1615.
Weis, W., et al. (1992), Nature 360, 127-134.
Heerze, L., et al. (1992), J. Biol. Chem. 267, 25810-25815.
Wright, C. (1990), J. Molec. Biol. 215, 635-651.
Cortina, G. and Barbieri J. (1991), J. Biol. Chem. 266, 3022-3030.
Klein, P., et al. (1985), Biochim. Biophys. Acta 815, 468-476.
Weis, W. et al. (1990) J. Molec. Biol. 212, 737-761.
Breg, J. (1989) Eur. J. Biochem. 178, 727-739.
Shigeta R. (1994) Acta Crystallagr D50, 71-74.
Armstrong, G. and Peppler M. (1987), Infect. Immun. 55, 1294-1299.
Allen, F. (1973), Cambridge Crystallagraphic Data Center. 2. Structural Data File K. Chem. Doc. 13, 119.
Kaslow, H., et al. (1989), J. Biol. Chem. 264, 6386-6390.
Zealey, G. et al. (1990) Biol. Tech. 8, 1025-1029.
Zealey, G. et al. (1992) Appl. Environ. Microbiol. 58, 208-214.
Krueger, K.M. and Barbieri, J.T. (1993), J. Biol. Chem. 268, 12570-12578.
Ditta, G., T. Schmidhauser, E. Yakobson, P. Lu, X.-W. Liang, D.R. Finlay, D. Guiney, and D.R. Helinski (1985) Plasmid 13:149-153.
Armstrong Glen D.
Cockle Stephen A.
Hazes Bart
Klein Michel H.
Loosmore Sheena
Connaught Laboratories Limited
Saidha Tekchand
University of Alberta
Wax Robert A.
LandOfFree
Modification of pertussis toxin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modification of pertussis toxin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modification of pertussis toxin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-651139