Amino acids useful as inhibitors of the advanced glycosylation o

Details Amino acids useful as inhibitors of the advanced glycosylation o Amino acids useful as inhibitors of the advanced glycosylation o

1992-01-27

1994-08-02

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514561, 514564, 514567, 514824, 514825, 514866, A61K 31195

Patent

active

053346173

ABSTRACT:
The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents are amino acids and their derivatives which contain an active nitrogen-containing group. Particular agents comprise lysine and mixtures thereof. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

REFERENCES:
CA 103(15): 115893f, Ceriello et al., 1985.
The Merck Index, 11th ed., #'s 441, 2787, 5509, 6826, 7029 (1989).
Nakamura et al., Amino Acids, 1, pp. 263-278 (1991), "Prevention and Reversible Solubilization of Advanced Glycation and Products (AGE) by Organic Germanium Compounds as Derivatives of Amino Acids".
Lubec et al., Nephron, 56, pp. 281-284 (1990), "The Effect of Substance L on Glucose-Mediated Cross-Links of Collagen in the Diabetic db/db Mouse".

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