Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Halogenated hydrocarbon doai
Patent
1987-03-20
1990-01-23
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Halogenated hydrocarbon doai
5142312, 514315, 514451, 514461, 514723, 514749, 514743, 514751, 514755, 514756, 514757, 514758, 514759, 514760, 514761, A61K 3135, A61K 31334, A61K 31445, A61K 31535
Patent
active
048958760
ABSTRACT:
A stable concentrated aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood. The emulsion can optionally include additional emulsifiers of SURFYNOL.RTM.SE surfactant and PLURONIC.RTM. P-105 surfactant. The emulsion is produced using an improved emulsification technique. The invention includes methods of oxygen transport in vascular systems wherein the oxygen carrying capacity of the vascular systems is improved with the emulsions of the present invention. Methods are also described for organ preservation extra-vivo by perfusing, suffusing, flushing and filling organs outside the body with the oxygen carrying emulsions of the present invention. Finally, methods of synthesis of the emulsions by emulsifying the components and aqueous medium using high shear mixing is also described.
REFERENCES:
patent: 3962439 (1976-06-01), Yokoyama et al.
patent: 4397870 (1983-08-01), Sloviter
patent: 4423077 (1983-12-01), Sloviter
patent: 4443480 (1984-04-01), Clark, Jr.
patent: 4497829 (1985-02-01), Sloviter
patent: 4533254 (1985-08-01), Cook et al.
patent: 4866096 (1989-09-01), Schweighardt
L. C. Clark, Jr., "Pathophysiology of Shock, Anoxia, and Aschemia", p. 507, Williams and Wilkins Publishers (1982).
Dr. Robert Geyer, "Synthesis and Biological Screening of New and Improved Fluorocarbon Compounds for Use as Artificial Blood Substitues", Harvard University School of Public Health (RFP-NHLI-HB-75-19).
Edward M. Levine et al, "Artificial Blood" on the Laboratory Horizon (LAB World).
Jean G. Riess, "Reassessment of Criteria for the Selection of Perfluorochemicals for Second Generation Blood Substitutes. Analysis of Struture/Property Relationships", published in Artificial Organs, 8(1):44-56, Raven Press, New York 1984.
Industrial and Engineering Chemistry, vol. 39, p. 380 (1949), Journal of Chemical Society, 1950, p. 3617 and Advance of Fluorine Chemistry, vol. I, p. 129 (1960).
Kayhart Charles R.
Schweighardt Frank K.
Air Products and Chemicals Inc.
Chase Geoffrey L.
Higel Floyd D.
Marsh William F.
Simmons James C.
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