Process for the production of N-substituted .alpha.-ketocarboxyl

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260557R, 260558R, 260559R, 260561R, 260561K, C07C10208, C07D30754

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042242266

ABSTRACT:
Compounds are prepared of the formula ##STR1## where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl groups or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formula

REFERENCES:
patent: 3257420 (1966-06-01), Szarvasi et al.
patent: 4096184 (1978-06-01), Nakamura et al.
Ritter et al., Journal of the American Chemical Society, vol. 70, (1948), pp. 4045 to 4050.
Ugi et al., Chem. Ber., vol 94, (1961), pp. 1116 to 1121.

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