Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines

Details Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines

1993-05-24

1995-05-16

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

556441, 560 51, C07D48704, C07B 3710

Patent

active

054162114

ABSTRACT:
Processes for preparing 5-substituted pyrrolo[2,3-d]pyrimidines which are useful as intermediates for the preparation of pyrrolo[2,3-d]pyrimidine antineoplastic agents or as antineoplastic agents themselves are provided.

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Noell, C. W., et al., J. Heterocyclic Chem., 1, 34-41 (1964).
Kandasamy Ramasamy, et al., J. Chem. Soc. Chem. Commun. 560-562 (1989).
Secrist, J. A., et al., J. Org. Chem., 43, 3937-3941 (1978).
DeGraw, J. I., et al., J. Med. Chem., 25, 1227-1230 (1982).
Taylor, C. E., et al., J. Org. Chem., 55, 3222-3227 (1990).

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