Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-01-23
1998-04-14
McKane, Joseph
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
564503, C07D20708, C07C21506
Patent
active
057393540
ABSTRACT:
The present invention relates to a novel process for preparing preparing oro-2-oxohexyl!-L-prolinamide or a pharmaceutically acceptable salt thereof and to a key intermediate by directly guanylating Dakin-West intermediates.
REFERENCES:
patent: 4061625 (1977-12-01), Af Ekenstam et al.
patent: 4216142 (1980-08-01), Ali
patent: 4217269 (1980-08-01), Cole
patent: 4247454 (1981-01-01), Af Ekenstam et al.
patent: 4275153 (1981-06-01), Gargiulo et al.
patent: 4318904 (1982-03-01), Shaw et al.
patent: 4399065 (1983-08-01), Bajusz et al.
patent: 4450105 (1984-05-01), Nagasawa et al.
patent: 4478745 (1984-10-01), Bajusz et al.
patent: 4607047 (1986-08-01), Debay
patent: 4643991 (1987-02-01), Digenis et al.
patent: 4703036 (1987-10-01), Bajusz et al.
patent: 4720484 (1988-01-01), Vincent et al.
patent: 4762821 (1988-08-01), Nestor
patent: 4816562 (1989-03-01), Verdini et al.
patent: 4826814 (1989-05-01), Sawayama et al.
patent: 4847401 (1989-07-01), Gerhart et al.
patent: 4880780 (1989-11-01), Trainor et al.
patent: 4929602 (1990-05-01), Harker et al.
patent: 4980349 (1990-12-01), Roger et al.
patent: 5053392 (1991-10-01), Klein et al.
patent: 5391705 (1995-02-01), Neises et al.
patent: 5498779 (1996-03-01), Neises et al.
Pitzele, Barrett S., J. Med. Chem, 1994, vol. 37, pp. 888-896.
Shuman, Robert T., J. Med. Chem 1993, vol. 36, pp. 314-319.
Chem Absts, vol 110, p. 709, 1989, No. 76058; Angliker, "Synthesis and properties of peptidyl derivatives of arginylfluoromethames" (Biochemical Journal, vol 256, No. 2, pp. 481-486.
Angliker et al., Biochem.J. 256(2), 481-6 (1988).
Gelb et al., "Fluoro Ketone inhibitors of Hydrolytic Enzymes," Biochemistry, vol. 24, No. 8, pp. 1813-1817, 1985.
Sham et al., "Highly potent and specific inhibitors of human renin", FEBS Letters, vol. 220, No. 2, pp. 299-301, 1987.
Chem Absts, vol. 107, 1987, No. 40336Y, p. 758; Stueber, M: Oligopeptidylargininol derivatives and their homologs, their use as antithrombics and agents containing them.
Shuman et al., Proceedings of the 12th American Peptide Symposium, pp. 801-802, (1991).
Kolb et al, Tetrahedron Lettes vol. 27, No. 14, pp. 1579-1582 (1986).
Kolb et al, Tetrahedron Lettes vol. 27, No. 37, pp. 4437-4440 (1986).
Kolb, M., et al, Liebigs Ann. Chem., pp. 1-6, (1990).
Peet N. P., et al, J. Med. Chem. 33, pp. 394-407, (1990).
Neises, B., et al Journal of the International Society on Thrombosis and Haemostasis, Abstracts p. 1290, 1991.
Neises, B., et al Journal of the International Society on Thrombosis and Haemostatis, Abstracts p. 1290, 1992.
Neises et al., Bioorganic & Medicinal Chemistry, vol. 3, No. 8, pp. 1049-1061, 1995, Synthesis and Comparison of Tripeptidylfluoroalkane Thrombin Inhibitors.
Begue et al, Tetrahedron, vol. 47, No. 20/21, pp. 3207-3258, Jan. 21, 1991.
Broersma et al., Thrombosis and Haemostasis 69, 666 (1993).
Derwent Abstract, EP 0 185 390, Jun. 25, 1986.
Derwent Abstract, EP 0 192 135, Feb. 18, 1985.
Hoffmann, et al, N'-Formyl-L-Lysine in Peptide Synthesis, Jul. 20, 1960, Studies in Polypeptides. XVI. The Preparation of N'-Formyl-L-lysine and its Application to the Synthesis of Peptides, pp. 3727-3732.
Narayanan et al, J. Med. Chem. 1994, 37, 885-887, SDynthesis of L-Thiocitrulline, L-Homothiocitrulline, and S-Methyl-L-thiocitrulline: A New Class of Potential Nitric Oxide Synthase Inhibitors.
Hoechst Marion Roussel Inc.
McKane Joseph
Payne T. Helen
LandOfFree
Process for the preparation of luoro-2-oxohexyl!-L-prolinamide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of luoro-2-oxohexyl!-L-prolinamide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of luoro-2-oxohexyl!-L-prolinamide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-636354