Inverted chimeric and hybrid oligonucleotides

Details Inverted chimeric and hybrid oligonucleotides Inverted chimeric and hybrid oligonucleotides

1995-08-17

1997-07-29

Elliott, George G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, C07H 2104, A61K 4800

Patent

active

056523564

ABSTRACT:
The invention relates to modified oligonucleotides that are useful for studies of gene expression and for the antisense therapeutic approach. The invention provides inverted hybrid oligonucleotides and inverted chimeric oligonucleotides, both of which produce reduced side effects, relative to traditional phosphorothioate, hybrid or chimeric oligonucleotides.

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