Avermectin epoxide derivatives and method of use

Details Avermectin epoxide derivatives and method of use Avermectin epoxide derivatives and method of use

1983-10-03

1985-07-23

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 536 71, 549264, 549265, A61K 3135, A61K 3171, C07H 1708

Patent

active

045309213

ABSTRACT:
There are disclosed novel avermectin compounds wherein certain double bonds are oxidized to epoxides. The epoxides are prepared by oxidizing an avermectin compound with a mild oxidizing agent. The avermectin epoxide compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.

REFERENCES:
patent: 4056616 (1977-11-01), Reimann et al.
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4206205 (1980-06-01), Mrozik et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.
patent: 4454314 (1984-06-01), Nagel
Derwent Abstract 84544E/40, Feb. 23, 1981.
Derwent Abstract 84545E/40, Feb. 23, 1981.

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