Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-03-15
1997-07-29
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514913, A67K 3114
Patent
active
056522720
ABSTRACT:
The present invention provides an ophthalmic preparation for reducing intraocular pressure comprising 2-[3-dimethyl-amino-2-(2-carboxyethoxy)propionyloxy]-2'-methoxybibenzyl or a salt thereof, which preparation exhibits intraocular pressure reducing activity, without exerting effects on the central nervous system, and can advantageously be used as a prophylactic and therapeutic agent for ocular hypertension and glaucoma bringing about elevated intraocular pressure.
REFERENCES:
British Journal of Ophthalmology--"Effect of Topical Ketanserin . . . Pressure", pp. 344-348, 1993.
Journal of Ocular Pharmacology--"Effect of Serotonin . . . ", Krootila, et al, pp. 279-290, 1987.
Drugs of the Future 1992, 17(12): 1093-1096--"Sarpogrelate Hydrochloride".
3390-377--Abstract--"The Effect of Anplag . . . Glaucoma Patients", M. Takenaka et al., 1995.
3322-309--Abstract--"The Effect of Anplac . . . Intraocular Pressure in Rabbits", T. Mano et al., 1995.
Journal of Pharmacobio-Dynamics--vol. 14, No. 4, Apr. 1991 pp. 177-181.
Deguchi Takaaki
Ogawa Takahiro
Fay Zohreh
Senju Pharmaceutical Co. Ltd.
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