Use of secretory products of human lacrimal gland acinar epithel

Details Use of secretory products of human lacrimal gland acinar epithel Use of secretory products of human lacrimal gland acinar epithel

1994-04-29

1997-07-29

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514912, A61K 3818

Patent

active

056522096

ABSTRACT:
The present invention relates to medicinal compositions and more particularly refers to such compositions for tear replacement therapy having products of human lacrimal gland acinar epithelia, and more specifically, growth factors or cytokines, in particular, the transforming growth factor beta (TGF.beta.).

REFERENCES:
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patent: 5023090 (1991-06-01), Levin
patent: 5064655 (1991-11-01), Uster et al.
patent: 5212162 (1993-05-01), Missel et al.
Kenichi Yoshino, Scheffer C.G. Tseng, Stephen C. Pugfelder, The Characterization of Human Lacrimal Gland Acinar and Ductal Epithelia in Various Culture Systems, Proceedings of the Fourth International Symposium, Tokyo, Japan, Aug. 11-13, 1993, M. Homma, S. Sugai, T. Tojo, N. Miyasaka, M. Akizuki, edtiros, pp. 1-4.
Steven E. Wilson, Scott A. Lloyd, Robert H. Kennedy, Basic Fibroblast Growth Factor (FGFb) and Epidermal Growth Factor (EGF) Receptor Messenger RNA Production in Human Lacrimal Gland, Investigative Opthalmology & Visual Science, vol. 32, No. 10, Sep. 1991, pp. 2816-2820.
Sjogren's Syndrome Foundation, Inc. Newsletter, Mar. 1994--Cytokine Profiles in SS and Guides to New Therapy, Noriyoshi Ogawa, MD, PhD.
Z. Ji, K. Yoshino, D. Monroy, S.C. Pflugfelder, Transforming Growth Factor .beta. (TGF.beta.) Expression in the Human Lacrimal Gland, Investigative Ophthalmology & Visual Science, Mar. 15, 1994, vol. 35, No. 4, p. 1792.
A. Gupta, K. Yoshino, S.C. Pflugfelder, The Identification of Transforming Growth Factor Beta-A in Carbachol-Stimulated Cultured Lacrimal Gland Acinar Cell Supernatant and Human Tears Using Sandwich Elisa Techniques, 1990 ARBO Abstract Form, Abstract to be Published in Investigative Ophthalmology & Visual Science, Mar. 15, 1994, vol. 35, No. 4, p. 1792.
K. Yoshino, A. Gupta, S.C.G. Tseng and S.C. Pflugfelder, Tear Protein Synthesis and diGA Uptake in Human Lacrimal Gland Acinar Culture, Investigative Ophthamology & Visual Science, Mar. 15, 1994, vol. 35, No. 4, p. 1792.
Chemical Abstract 120 : 124917 (1991), Glaser et al.

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