Nucleozymes

Details Nucleozymes Nucleozymes

1992-01-31

1997-07-29

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 9131, 4351721, 4351723, 536 231, 536 232, 536 245, 514 44, C12Q 168, C12N 1500

Patent

active

056520948

ABSTRACT:
Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts. Also described are methods for preparing the nucleozymes along with methods of using nucleozymes, e.g., as therapeutic agents.

REFERENCES:
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Strobel and Cech., Biochemistry 32:13593, 1993: "Tertiary Interactions with the Internal Guide Sequence Mediate Docking of the Pl Helix into the Catalytic Core of the T. Ribozyme".

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