Amyloid precursor proteins and method of using same to assess ag

Details Amyloid precursor proteins and method of using same to assess ag Amyloid precursor proteins and method of using same to assess ag

1995-06-05

1997-07-29

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 71, 435 691, 4351723, 530350, 530839, C07K 14435, C12N 121, C12N 510, C12N 1512

Patent

active

056520921

ABSTRACT:
This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, about 475 or about 494 amino acid residues in which a portion thereof encodes a .beta.-amyloid protein domain. Also described is a method for screening for a compound which reduces the formation of .beta.-amyloid protein.

REFERENCES:
patent: 5348963 (1994-09-01), Gandy
Sahasrabudhe, S.R. et al; J. Biol. Chem. 267:25602-25608 (1992).
Vitek, M.P. et al., Soc. Neurosci. Abstr. 17(1-2):1443 (1991).

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