Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1992-12-30
1998-04-14
Kight, John
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 169, 424 91, 424 111, 424 93, 530300, 530326, 530330, 534 10, 534 14, 534 15, A61K 4900, G01N 3315
Patent
active
057388385
ABSTRACT:
Peptides useful for lung imaging, and preferably containing a biological-function domain which includes the sequence Ile-Lys-Val-Ala-Val (IKVAV) (SEQ. ID NO. 1) and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in a variety of diseases and pathologic conditions, and particularly diagnostic imaging of diseases and pathologic conditions of the lung.
REFERENCES:
patent: 4427646 (1984-01-01), Olexa et al.
patent: 4479930 (1984-10-01), Hnatowich
patent: 4668503 (1987-05-01), Hnatowich
patent: 4732864 (1988-03-01), Tolman
patent: 4877868 (1989-10-01), Reno et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 5330911 (1994-07-01), Hubbell et al.
patent: 5346687 (1994-09-01), Rhodes
patent: 5371184 (1994-12-01), Rajagopalan et al.
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5460785 (1995-10-01), Rhodes et al.
Anger, K, "Radionuclide Studies of the Lung" Sperber, editor, Radiologic Diagnosis of Chest Disease, Springer-Verlag, New York pp. 140-153 (1990).
Clement, B, "Hepatocyte Attachment to Laminin Is Mediated Through Multiple Receptors", J. of Cell Biology, vol. 110, pp. 185-192 (1990).
Hynes, R.O., "Integrins: Versatility, Modulation, and Signalling in Cell Adhesion", Cell. vol. 69, pp. 11-25 (1992).
Kleinman, H.K., "Identification of a 110-kDa Nonintegrin Cell Surface Laminin-Binding Protein Which Recognizes an A Chain Neurite-Promoting Peptide", Archives of Biochem, vol. 290 No. 2, pp. 320-325 (1991).
Kanemoto, T., et al., "Identification of an Amino Acid Sequence from the Laminin A Chain that Stimulates Metastasis and Collagenase IV Production", Proc. Nat. Acad. Sci. (USA), vol. 87 pp. 2279-2283 (1990).
Miller, R.F., et al., "Pulmonary Nuclear Medicine", Eur. J. Nucl. Med., vol. 19, pp. 355-368 (1992).
Nomizu, M., et al., "The All-D-Configuration Segment Containing the IKVAV Sequence of Laminin A. Chain has Similar Activities fo the All-L-Peptide In Vitro and In Vivo", J. Biol. Chem., vol. 267, pp. 14188-14121 (1992).
Sephel, G.C., "Laminin A Chain Synthetic Peptide Which Supports Neurite Outgrowth", Biochem. Biophys. Res. Comm., vol. 162, pp. 821-829 (1989).
Skubitz, A.P., "Synthetic peptides from the Carbosy-terminal Globular Domain of the A Chainof Laminin: Their Ability to Promote Cell Adhesion and Neurite Outgrowth, and Interact with Peparin and the Beta1 Integrin Subunit", J. Cell Biol., vol. 115, pp. 1137-1148 (1991).
Tashiro, Ken-Ichiro, et al., "A Synthetic Peptide Containing the IKVAV Sequence from the Chain of Laminin Mediates Cell Attachment, Migration, and Neurite Outgrowth", J. Biol. Chem., vol. 27, pp. 16174-16182 (1989).
Tetalman, M.R., et al., "Perfusion Scans in Normal Volunteers", Radiology, vol. 106, pp. 593-594 (1973).
Thompson, H.L., et al., "Mast Cells Chemotax to Laminin with Enhancement After IgE-Mediated Activation", J. Immunol., vol. 143, pp. 4188-4192 (1989).
Thompson, H.L., et al., "Identification of an Amino Acid Sequence in the Laminin A Chain Mediating Mast Cell Attachment and Spreading", Immunology, vol. 72, pp. 144-149 (1991).
Webber, M.M., et al., "Variants of the Normal Lung Scan: Correlation with Pulmonary Function Tests", J. Nucl. Med., vol. 13, p. 476 (1972).
Yamada, K.M., et al., "Adhesive Recognition Sequences", J. Biol. Chem., vol. 266, pp. 2809-2812 (1992).
Pimm, M.V., et al., "In labelling of a branched polypeptide drug carrier with a poly (L-lysine-backbone," Int'l J. Pharm., vol. 79, pp. 77-80 (1992).
Zamora, P.O., et al., Lung Uptake of 99mTc-Laminin Peptide PA22-2 Is Decreased in Emphysema and Increased in Tumored Lung, Abstract, J. Nucl. Med., vol. 34, No. 5, (1993), Abstract No. 1133.
Zamora, P.O, et al., Biological distribution of 99mTc-labeled.
Yigsr and IKVAV laminin peptides in rodents: 99mTc-IKVAV peptide localizes to the lung, Biochemica et Biophysica Acta, vol. 1182, No. 2 (1993), p. 197-204.
Sandrock, B., "Kinetics of I.V. Injected 1-131-Labeled Laminin-C.sub.1 -Fragmen in Normal and Tumor-Bearing Nude Mice," Proceedingsof the AACR, vol. 30, Abstract No. 390 (1989).
Liotta, Lance A., Laminin Receptors on Human Breast Carcinoma: Role in.
Invasion of the Extracellular Matrix, Understanding Breast Cancer: Clinical and Laboratory Concepts, Rich, N, et al (ed.). pp. 87-97 (1983).
Zamora, P.O., et al., "A Second Tc-99m Binding Site In IgG Is Related To Distadine Groups," J. Nucl. Med., vol. 33, No. 5 (1992), Abstract No. 868.
Fischman, Alan J., et al., "A Ticket to Ride: Peptide Radiopharmaceuticals," Journal of Nucl. Med., vol. 34, No. 12, pp. 2253-2263 (Dec. 1993).
Jones D. L.
Kight John
RhoMed Incorporated
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