Process for preparing prostacyclins

Details Process for preparing prostacyclins Process for preparing prostacyclins

1983-12-21

1986-03-25

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549305, 549415, 549465, 544153, 546196, 548525, C07D307935

Patent

active

045784825

ABSTRACT:
A process for producing prostacyclins of the formula ##STR1## wherein the symbol G.sup.1, R.sup.1, R.sup.2, R.sup.31 and R.sup.41 are as defined in claim 1,
which comprises reacting 5,6-dehydroprostaglandins F.sub.2 of the formula ##STR2## wherein the symbol G, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in claim 1,
with a mercury (II) compound in an inert organic solvent in the presence of tri(C.sub.1 -C.sub.6)alkylamine, treating the reaction product with a boron hydride compound, and if necessary, subjecting the reaction product to deprotecting reaction, hydrolysis reaction, or salt-forming reaction.
This process is industrially advantageous process for the preparation of prostacyclin and its derivatives.

REFERENCES:
Suzuki et al., Tet. Letters, 24 (11), pp. 1187-1188 (Mar. 1983).
Riediker et al., J.A.C.S. 104, pp. 5842-5844 (1982).
Bach et al., J. Org. Chem. 47, pp. 3707-3712 (1982).

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