Pharmaceutical compositions comprising an anticytokine

Details Pharmaceutical compositions comprising an anticytokine Pharmaceutical compositions comprising an anticytokine

1992-05-07

1996-04-30

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530350, A61K 3816, A61K 3817, C07K 14435, C07K 1447

Patent

active

055125441

ABSTRACT:
Tumor Necrosis Factor Binding Proteins (TBPs) are useful in the treatment of autoimmune diseases and graft-versus-host reactions.

REFERENCES:
Beutler et al. "Cachectin: More Than A Tumor Necrosis Factor" New England J Med. 316(7) 379-385 1987.
Tracey et al. "Cachectin/Tumour Necrosis Factor" Lancet 1 1122-1125 1989.
Herrison's Principles of Internal Medicine pp. 1571-1575 1991.
Osband et al. "Problems in The Investigational Study & Chemical Use of Cancer Immuno Therapy" Immunol Today 11(6) 193-195 1990.
Engelmann et al J.B.C. vol. 264 No. 20 (7/89) pp. 11974-11980.
D. Aderka et al., "The Possible Role of Tumor Necrosis Factor (TNF) and its Natural Inhibitors, the Soluble-TNF Receptors, in Autoimmune Diseases", Israel Journal of Medical Sciences, vol. 28, No. 22, pp.: 126-130. 1992.
T. Kohno et al., "A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor", Proc. Natl. Acad. Sci., vol. 87, pp.: 8331-8335. 1990.
H. Loetscher et al., "Molecular Cloning and Expression of the Human 55kd Tumor Necrosis Factor Receptor", Cell, vol. 61, pp.: 351-359. 1990.
T. J. Schall et al., "Molecular Cloning and Expression of a Receptor for Human Tumor Necrosis Factor", Cell, vol. 61, pp.: 361-370. 1990.
Y. Nophar et al., "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor", The EMBO Journal, vol. 9, No. 10, pp.: 3269-3278. 1990.
P. Seckinger et al., "Purification and biologic Characterization of a Specific Tumor Necrosis Factor .alpha. Inhibitor", The Journal of Biological Chemistry, vol. 264, No. 20, pp.: 11966-11973. 1989.
I. Olsson et al., "Isolation and characterization of a tumor necrosis factor binding protein from urine", Eur J Haematol, 1989; 42:270-275.
H. Engelmann et al., "Two Tumor Necrosis Factor-binding Proteins Purified from Human Urine", Journal of Biological Chemistry, vol. 265, No. 3, pp.: 1531-1536. 1990.
H. Engelmann et al., "A Tumor Necrosis Factor-binding Purified to Homogeneity from Human Urine Protects Cells from Tumor Necrosis Factor Toxicity", vol. 264, No. 20, pp.: 11974-11980. 1989.

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