Method for determining bladder tumors by assaying for MAGE-1,2,3

Details Method for determining bladder tumors by assaying for MAGE-1,2,3 Method for determining bladder tumors by assaying for MAGE-1,2,3

1994-11-30

1996-04-30

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 435 79, 435 912, 536 231, 536 243, C12Q 168, C12P 1934, C07H 2104, G01N 3353

Patent

active

055124445

ABSTRACT:
A method for screening for bladder cancer by identifying expression of one or more of MAGE-1, MAGE-2, MAGE-3 and MAGE-4 is the disclosed invention. Expression can be determined by a number of methods, including nucleotide amplification assays.

REFERENCES:
Van der Bruggen et al., "A Gene Encoding An Antigen Recognized By Cytolytic T Lymphocytes On A Human Melanoma", Science 254: 1643-1647 (Dec. 13, 1991).
Brasseur, et al., "Human gene MAGE-1, which codes for a tumor rejection antigen, is expressed by some breast tumors", Int. J. Cancer 52: 839-841 (1992).
Gaugler et al., "Human Gene MAGE-3 Codes for an Antigen Recognized on a Melanoma by Autologous Cytolytic T Lymphocytes", J. Exp. Med. 179: 921-930 (1994).

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