Giardia vaccine

Details Giardia vaccine Giardia vaccine

1993-11-23

1996-04-30

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

4242651, 4352581, A61K 39002, C12N 110

Patent

active

055122884

ABSTRACT:
The invention provides a method of preventing or treating Giardia infection in dogs and cats by adminstering Giardia which has been cultured in media containing bile so as to make it protectively immunogenic.

REFERENCES:
patent: 4238478 (1980-12-01), Stojkovic
patent: 4314992 (1982-02-01), Bitakaramire et al.
patent: 4404186 (1983-09-01), Ron
patent: 4493825 (1985-01-01), Platt et al.
patent: 4639372 (1987-01-01), Murray
patent: 4687666 (1987-08-01), O'Daly et al.
patent: 4724145 (1988-02-01), Murray et al.
patent: 4808404 (1989-02-01), Bhogal
patent: 4837016 (1989-06-01), Holder et al.
patent: 5028694 (1991-07-01), Mewman, Jr. et al.
patent: 5045313 (1991-09-01), Frenkel et al.
patent: 5077044 (1991-12-01), Stocker
Gupta et al, Biol Mem. 18 (1,2):23-27, 1992.
Nash T. E., Experimental Purisitology 68:238-241 (1989).
Gillin et al, Experimental Purisitology 69:164-174 (1989).
Halliday et al, Transactions of the Royal Society of Tropical Medicine & Hygiene 82:428-432. (1988).
Gillin, et al., "Encystation and Expression of Cyst Antigens by Giardia lamblia in Vitro," Science: Materials Science, 235:1040-1043 (1987).
Gillin, et al., "Small-Intestinal Factors Promote Encystation of Giardia lamblia in Vitro," Infection and Immunity, 56:705-707 (1988).
Katelaris, et al., "Bile Modulates Genotypic and Phenotypic Characterisitcs of Giardia lamblia," Gut, 32:1089 (1991).
Adam, The biology of Giardia spp., Microbiology Rev., 55 (4): 706-732 (1991).
Anders, et al., Giardiassis in mice: analysis of humoral and cellular immune responses to Giardia muris, Parasite Immunology, 4:47-57 (1982).
Belosevic, et al., Observations on natural and experimental infections with giardia isolated from cats, Can. J. Comp. Med., 48:241-244 (1984).
Bemrick, et al., Giardiasis--is it really a zoonosis?, Parasitology Today, 4 (3): 69-71 (1988).
Bulow, et al., Protection of mice from fatal toxoplasma gandii infection by immunization with p30 antigen in liposomes.sup.1, J. of Immun., 147 (10): 3496-3500 (1991).
Buret, et al., Pathophysiology of small intestinal malabsorption in gerbils infected with Giardia lamblia, Gastroenterology, 103: 506-513 (1992).
Buret, et al., Growth, activities of enzymes in the small intestine, and ultrastructure of microvillus border in gerbils infected with Giardia duodenalis, Parasitol Res., 77: 109-114 (1991).
Buret, et al., Effects of murine giardiasis on growth, intestinal morphology and disaccharidase activity, J. Parasitol, 76 (3): 403-409 (1990).
Buret, et al., Zoonotic potential of giardiasis in domestic ruminants, J. Infect. Dis., 162: 231-237 (1990).
Butscher, et al., The therapeutic action of monoclonal antibodies against surface glycoprotein of Giardia muris, Immunology, 64: 175-180 (1988).
Buxton, et al., Vaccination of sheep with a live incomplete strain (S48) of toxomplasma gondii and their immunity to challenge when pregnant, Vet. Record, 129: 89-93 (1991).
Capon, et al., Similarities of Giardia Antigens Derived From Human and Animal Sources, Int'l. J. for Parasitol, 19 (1):91-98 (1989).
Capron, et al., Nouvelles approaches moleculaires dans le diagnostic et la prevention de la toxoplasmose, Bull. Acad. Natle. Med., 174 (3): 387-394 (1990) (English version starts on p. 390).
Cesbron-Delauw, et al., Molecular characterization of a 23-kilodalton major antigen secreted by toxoplasma gondii, Proc. Natl. Acad. Sci. USA, 86: 7537-7541 (1989).
Dahl, et al., Recognition by the human immune system of candidate vaccine epitopes of toxoplasma gondii measured by a competitive ELISA, Vaccine 5: 187-191 (1987).
denHollander, et al., Immunology of Giardiasis, Parasitiology Today, 4 (5): 124-130 (1988).
Duquesne, et al., Identification of T cell epitopes within a 23-kD antigen (P24) of toxoplasma gondii, Clin. Exp. Immun., 84: 527-534 (1991).
Edson, et al., An 88,000-M.sub.r Giardia lamblia Surface Protein Which Is Immunogenic in Humans, Infection and Immunity, 54 (3):621-625 (1986).
Escajadillo, et al., Experimental toxoplasmosis and vaccine tests in aotus monkeys, Am. J. Trop. Med. Hyg. 44 (4): 382-389 (1991).
Farthing, et al., Mammalian bile promotes growth of Giardia lamblia in axenic culture, Transactions of The Royal Soc. of Trop. Med. and Hygiene, 77 (4): 467-469 (1983).
Faubert, Evidence that giardiasis is a zoonosis, Parasitology Today, 4 (3): 66-71 (1988).
Feely, et al., The biology of Giardia, "Human Parasitic Diseases, 3: --Giardiasis", Meyer Ed., Elsevier Sci. Pub., 11-49 (1990).
Frenkel, et al., Prospective vaccine prepared from a new mutant of toxoplasma gondii for use in cat, Am. J. Vet. Res., 52 (10): 759-763 (1991).
Gazzinelli, Synergistic role of CD4.sup.+ and CD8.sup.+ T lymphocytes in ifny production and protective immunity induced by an attenuated toxoplasma gondii vaccine, J. of Immun., 146 (1): 286-292 (1991).
Gillin, et al., Secretory defenses against Giardia lamblia, Immun. of Milk and the Neonate, Mestecky, et al., Ed., Plenum Press, 227-233 (1991).
Gillin, et al., Isolation and expression of the gene for a major surface protein of Giardia lamblia, Pro. Natl. Acad. Sci. USA, 87:4463-4467 (1990).
Gillon, et al., Changes in the small intestinal mucosa in giardiasis, "Giardia and Giardiasis", Erlandsen, et al., Eds., Plenum Press, 163-183 (1984).
Gottstein, et al., Human cellular immune response to Giardia lamblia, Infec., 19 (6): 421-426 (1991).
Hermentin, et al., Efforts towards a vaccine against toxoplasma gondii: a review, Zbl. Bakt. Hyg. A, 269: 423-436 (1988).
Hewlett, et al., Experimental infection of mongrel dogs with Giardia lamblia cysts and cultured trophozoites, J. of Infec. Dis., 145 (1): 89-93 (1982).
Heyworth, Immunology of giardia and cryptosporidium infections, J. of Infec. Dis., 166: 465-472 (1992).
Heyworth, Relative susceptibility of Giardia muris trophozoites to killing by mouse antibodies of different isotypes, J. Parasitol., 78 (1), 73-92 (1992).
Hill, et al., Giardia lamblia Infection of Suckling Mice, The Journal of Infectious Diseases, 124 (2):217-221 (1983).
Holmgren, Mucsal immunity and vaccination, FEMS Microbiology Immunology 89:1-10 (1991).
Istre, et al., Waterborne giardiasis at a mountain resort: evidence for acquired immunity, Am. J. Pub. Health, 74(6): 602-604 (1984).
Jakubowski, Purple burps and the filtration of drinking water supplies, Am. J. Pub. Health, 78 (2): 123-125 (1988).
Janoff, et al., The role of immunity in Giardia infections, "Human Parasitic Diseases, 3: --Giardiasis", Meyer Ed., Elsevier Sci. Pub., 215-235 (1990).
Janoff, et al., Acute antibody responses to Giardia lamblia are depressed in patients with AIDS, J. Infec. Dis., 157 (4): 798-804 (1988).
Katerlaris, et al., Diarrhoea and malabsorption in giardiasis: a multifactorial process? Gut., 33: 295-297 (1992).
Katelaris, et al., Pathogenesis of diarrhea caused by Giardia lamblia: evidence for an exotoxin. J. Gastroenterol. Hepatol., 3 (suppl 1): A4 (1988).
Keister, Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile, Transactions of The Royal Soc. of Trop. Med. and Hygiene, 77 (4): 487-488 (1983).
Kirkpatrick, et al., Feline giardiasis, observations on natural and induced infections, Am. J. Vet. Res., 45 (10):2182-2188 (1984).
Ko, et al., Identification and characterization of a target antigen of a monoclonal antibody directed against Eimeria tenella morozoites, Molecular and Biochem. Parasitology, 41: 53-64 (1990).
Kum, et al., Characterization of surface associated antigens of axenic Giardia lamblia trophozoites & their recognition by human sera, Indian J. Med. Res., 93:40-46 (1991).
Lewis, et al., Cortisone-induced recrudescence of Giardia lamblia infections in gerbils, Am. J. Trop. Med. Hyg., 36 (1): 33-40 (1987).
Ljungstrom, et al., Immune response to Giardia lamblia in a water-borne outbreak of giardiasis in Sweden, J. Med. Microbiol., 36: 347-352 (1992).
LoGalbo, et al., Symptomatic giardiasis in three patients with X-linked agammaglobulinemia, J. Pediatrics, 101 (1): 78-80 (1982).
McLeod, et al., Subcutaneous and intestinal vaccination with tachyzoites of Toxoplasma gondii and acquistion of immunity to peroral and congenital

Affiliated with

Also associated with

Rating

Giardia vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Giardia vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Giardia vaccine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-626634