Method of enhancing lipophile transport using cyclodextrin deriv

Details Method of enhancing lipophile transport using cyclodextrin deriv Method of enhancing lipophile transport using cyclodextrin deriv

1987-07-01

1989-10-31

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514824, 536103, A61K 31715, C08B 3716

Patent

active

048777781

ABSTRACT:
Levels of cholesterol, vitamin A, triglycerides, and other lipophiles in the human circulation can be manipulated by intravenous infusion of cyclodextrin-type compounds. The cyclodextrin-type compound should be highly soluble in water, amorphous and of only moderate molecular weight in order to be easily excreted; one preferred cyclodextrin, 2-hydroxypropyl-.beta.-cyclodextrin with an average molecular weight of 1460, is administered at doses of 0.5 g/kg x day. The serum levels of the lipophiles indicate that the infusion may serve to mobilize the lipophile from tissues, induce its excretion, and furthermore affect its homeostasis.

REFERENCES:
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patent: 3459731 (1969-08-01), Gramera
patent: 4407795 (1983-10-01), Nicolau
Pitha and Szente, Life Sciences, 32:719-723, (1983).
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Pitha et al., Int'l. J. of Pharmaceutics 29:73-82, (1986).
Pitha and Szente, Int'l. Symp. on Cyclodextrins, Budapest, (1981).
Pitha, J. Inclusion Phenomena, 2:477-485, (1984).
Pitha and Pitha, J. Pharmaceutical Sciences, 74:987, (1985).
Pitha, Third Int'l. Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, Feb. 23-27, (1987).

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