Method of incorporating water-soluble heat-sensitive therapeutic

Details Method of incorporating water-soluble heat-sensitive therapeutic Method of incorporating water-soluble heat-sensitive therapeutic

1977-12-12

1982-11-02

Lovering, Richard D.

Compositions

Preservative agents

Anti-corrosion

252 6253, 252 6254, 424 1, 424 22, 424 36, 424181, 427338, B01J 1302, A01N 2528, A61K 964

Patent

active

043572596

ABSTRACT:
A method is provided for incorporating water-soluble therapeutic agents in albumin microspheres. This method is particularly advantageous where the therapeutic agent is heat-sensitive. All steps of the method can be carried out at relatively low temperatures, such as ambient room temperature. The method may be applied to the preparation of intravascularly-administrable, magnetically-responsive microspheres.

REFERENCES:
patent: 2989417 (1961-06-01), Overman
patent: 3137631 (1964-06-01), Soloway
patent: 3474777 (1969-10-01), Figge et al.
patent: 3663687 (1972-05-01), Evans
patent: 3937668 (1976-02-01), Zolle
Kramer: J. Pharm. Sci., 63, 1646-1647 (1974).
Zolle et al.: Int. J. Appl. Radiat., 21, 155-167 (1970).
Scheffel et al.: J. Nucl. Med., 13, 498-503 (1972).

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