Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-08-12
1990-05-15
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548544, 548453, C07D20738, A61K 3140
Patent
active
049258680
ABSTRACT:
The present invention relates to a compound of the formula: ##STR1## wherein X is sulfur or optionally substituted imino group; Y is a bond, oxygen, phenylene, phenyleneoxy, or oxyphenyleneoxy; R.sup.1 is hydrogen or optionally substituted hydrocarbon residue; R.sup.2 is optionally substituted hydrocarbon residue; and R.sup.1 may form, together with the imino-nitrogen atom as X, a nitrogen-containing 5- to 7-membered ring, production and use thereof.
The compound (I) of the present invention has an anti-oxidation activity and activities of preventing or improving functional disorders due to biologically active oxygen species, thus being useful as a pharmaceutical agent for prophylaxis and therapy of disorders in the circulatory system.
REFERENCES:
patent: 3401176 (1968-09-01), Hofmann et al.
Tsuzuki, Kazuo, et al., "Sulfur-Extrusive Rearrangement of .alpha.-Acylthio Ester by Lithium Amide", Bull. Chem. Soc. Jpn., vol. 58, pp. 395-396 (1985).
Schmierer, Roland, et al., "Cyclisierung von N-Acylalanin-und N-Acylglycinestern", Liebigs Ann. Chem., pp. 1095-1098 (1985).
Schmidlin, Tibur, et al., "Approaches to the Synthesis of Cytochalasans. Part 2. Pyrrolinone Derivates as Basic Units.sup.1).sup.2)", Helvetica Chimica Acta, vol. 63, pp. 121-131 (1980).
S. Suzuki, et al., "Studies on Antiviral Agents: Biological Activity of Tenuazonic Acid" Chem. Pharm. Bull. vol. 15, pp. 1120-1122 (1967).
Hirata Minoru
Terao Shinji
Springer David B.
Takeda Chemical Industries Ltd.
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