Topical hematoporphyrin

Details Topical hematoporphyrin Topical hematoporphyrin

1988-07-06

1990-05-15

Kight, III, John

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514185, 514969, 540145, A61K 3140, A61K 748, A61L 1504

Patent

active

049257366

ABSTRACT:
A topical hematoporphyrin composition, the method for its production, and a method for its use in the treatment of human papillomavirus disease are described. The hematoporphyrin composition is capable of being absorbed by diseased tissue, thus enabling destruction of the tissue upon exposure to 625 to 635nm light.

REFERENCES:
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patent: 4696905 (1987-09-01), Aoyama et al.
patent: 4753958 (1988-06-01), Weinstein et al.
Beani et al., "Problems poses par l'utilisation therapeutique des photosensibilisateurs en dermatologie", Biochimie, vol. 68, pp. 905-912 (1986).
Abramson et al., "Thermal Effects of Photodynamic Therapy on the Larynx", Arch. Otolaryngol. Head Neck Surg., vol. 113, pp. 854-858 (Aug. 1987).
Abramson et al., "The Pathologic Affects of Photodynamic Therapy on the Larynx", Arch. Otolaryngol Head Neck Search, vol. 114, pp. 33-39 (Jan. 1988).
Shikowitz et al., "Hematoporphyrin Derivative Therapy of Papillomas", Archives of Otolaryngology Head Neck Surg., vol. 112, pp. 42-46, (Jan. 1986).
Amano et al., "Intratumor Injection As A More Effective Means of Porphyrin Administration For Photodynamic Therapy", Journal of Urology, vol. 139, pp. 392-395 (Feb. 1988).
Dougherty et al., "The Structure of the Active Component of Hematophorphyrin Derivative", Porphyrin Localization and Treatment of Tumors, pp. 301-314, Copyright 1984.
Shikowitz et al., "Molecular Analysis of Cottontail Rabbit Papillomavirus-induced Papillomas Treated with Hematoporphyrin Photodynamic Therapy", Cancer Cells 5/Papillomaviruses, pp. 411-416 (1987).
Gomer et al., "Expression of Potentially Lethal Damage in Chinese Hamster Cells Exposed to Hematoporphyrin Derivative Photodynamic Therapy", Cancer Research, vol. 46, pp. 3348-3352 (Jul. 1986).
Benson, Jr., "Treatment of Diffuse Transitional Cell Carcinoma in Situ by Whole Bladder Hematoporphyrin Derivative Photodynamic Therapy", Journal of Urology, vol. 134, pp. 675-678 (Oct. 1985).
Gluckman et al., "Photodynamic Therapy", Arch. Otolaryngol. Head Neck Surg., vol. 112, pp. 949-952 (Sep. 1986).
Pathak et al., "The Nature and Molecular Basis of Cutaneous Photosensitivity Reactions to Psoralens and Coal Tar", Journal Invest. Der., vol. 80, No. 6, pp. 66s-73s (1983).
Grossman, "Diagnosis and Treatment of Bladder Carcinoma", Comprehensive Therapy, vol. 12, No. 8, pp. 42-47 (1986).
Zincke et al., "Review of Mayo Clinic Experience with Carcinoma in Situ", Supplement to Urology, vol. 26, No. 4 (1985).
McCullough et al., "Development of a Topical Hematoporphyrin Derivative Formulation: Characterization of Photosensitizing Effects in Vivo", Journal of Invest. Derm., vol. 81, No. 6, pp. 528-532 (1983).
McCullough et al., "Development of a Topical Hematoporphyrin Derivative (HPD) Formulation and Characterization of its Photosentizing Effects in Guinea Pig Skin", Abstract, vol. 78, No. 4, p. 356; Journal Invest. Derm.; and Clinical Research, vol. 30, No. 1, p. 158A (1982).
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